Paqr9 progestin and adipoQ receptor family member IX [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Paqr9provided by MGI
Official Full Name: progestin and adipoQ receptor family member IXprovided by MGI
Primary source: MGI:MGI:1922802
See related: Ensembl:ENSMUSG00000064225 AllianceGenome:MGI:1922802
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Blnc1; 1700020G04Rik; C730029A08Rik
Summary: Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. Is expressed in several structures, including ganglia; heart; liver lobe; and pancreas. Orthologous to human PAQR9 (progestin and adipoQ receptor family member 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 9; 9 E3.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (95441687..95450075)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (95559634..95568022)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in beta cells in vitro under stress conditions.
Title: PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in β cells in vitro under stress conditions.
Blnc1 forms a ribonucleoprotein complex with transcription factor EBF2 to stimulate the thermogenic gene program. Further, Blnc1 itself is a target of EBF2 forming a feedforward regulatory loop to drive adipogenesis toward thermogenic phenotype.
Title: A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation.
hepatic expression of the lncRNA Blnc1 is strongly elevated in obesity and nonalcoholic fatty liver disease in mice
Title: Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis.
Blnc1 attenuates proinflammatory cytokine signaling and promotes fuel storage in adipocytes through its protein partner Zbtb7b.
Title: The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic health.
Zbtb7b recruits the brown fat Blnc1/heterogeneous nuclear ribonucleoprotein U (hnRNPU) ribonucleoprotein complex to activate thermogenic gene expression in adipocytes.
Title: Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: membrane progesterone receptor epsilon

Names: brown fat lncRNA 1; mPR epsilon; membrane progesterone P4 receptor epsilon; membrane progestin receptor epsilon; progesterone and adipoQ receptor family member 9; progestin and adipoQ receptor family member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.