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    Ccsap centriole, cilia and spindle associated protein [ Mus musculus (house mouse) ]

    Gene ID: 73420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccsapprovided by MGI
    Official Full Name
    centriole, cilia and spindle associated proteinprovided by MGI
    Primary source
    MGI:MGI:1920670
    See related
    Ensembl:ENSMUSG00000031971 AllianceGenome:MGI:1920670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700054N08Rik
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in mitotic spindle microtubule depolymerization; regulation of embryonic development; and regulation of mitotic spindle assembly. Predicted to be located in centrosome; cilium; and mitotic spindle astral microtubule. Predicted to be active in axon; ciliary transition zone; and cytoskeleton. Is expressed in olfactory epithelium; telencephalon ventricular layer; and vomeronasal organ. Orthologous to human CCSAP (centriole, cilia and spindle associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 14.9), testis adult (RPKM 12.7) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccsap in Genome Data Viewer
    Location:
    8 E2; 8 72.22 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124566712..124586948, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123839973..123860209, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36188 Neighboring gene RAB4A, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_22987 Neighboring gene STARR-positive B cell enhancer ABC_E5049 Neighboring gene predicted gene 4342 Neighboring gene predicted gene 9901 Neighboring gene predicted gene, 36896 Neighboring gene predicted gene, 53468

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle microtubule depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary transition zone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitotic spindle astral microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle astral microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    centriole, cilia and spindle-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379289.1 → NP_001366218.1  centriole, cilia and spindle-associated protein

      Status: VALIDATED

      Source sequence(s)
      AC147266, AK006786, AK086180
      UniProtKB/Swiss-Prot
      Q8C3E1, Q8QZT2
      Related
      ENSMUSP00000034452.6, ENSMUST00000034452.12
      Conserved Domains (1) summary
      pfam15748
      Location:7 → 251
      CCSAP; Centriole, cilia and spindle-associated

    2. NM_028536.1 → NP_082812.1  centriole, cilia and spindle-associated protein

      See identical proteins and their annotated locations for NP_082812.1

      Status: VALIDATED

      Source sequence(s)
      BC036300
      Consensus CDS
      CCDS22763.1
      UniProtKB/Swiss-Prot
      Q8C3E1, Q8QZT2
      Related
      ENSMUSP00000113319.2, ENSMUST00000122421.2
      Conserved Domains (1) summary
      pfam15748
      Location:7 → 251
      CCSAP; Centriole, cilia and spindle-associated

    RNA

    1. NR_166592.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC147266

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      124566712..124586948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZT2.1 GenPept UniProtKB/Swiss-Prot:Q8QZT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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