Sirt3 sirtuin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sirt3provided by MGI
Official Full Name: sirtuin 3provided by MGI
Primary source: MGI:MGI:1927665
See related: Ensembl:ENSMUSG00000025486 AllianceGenome:MGI:1927665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sir2l3; 2310003L23Rik
Summary: Enables NAD-dependent protein lysine deacetylase activity and sequence-specific DNA binding activity. Involved in peptidyl-lysine deacetylation; positive regulation of ceramide biosynthetic process; and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation and protein deacetylation. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (sirtuin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 35.3), liver adult (RPKM 33.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F4- F5; 7 86.07 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (140443576..140462222, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (140863663..140882309, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of Sirtuin 3 in endothelial cells impairs endothelial-dependent relaxation and myogenic response in mice.
Title: Knockout of Sirtuin 3 in endothelial cells impairs endothelial-dependent relaxation and myogenic response in mice.
Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice.
Title: Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice.
Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis.
Title: Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis.
Intrauterine hyperglycemia induces SIRT3-mediated mitochondrial dysfunction: the fetal origin pathogenesis of precocious osteoarthritis.
Title: Intrauterine hyperglycemia induces SIRT3-mediated mitochondrial dysfunction: the fetal origin pathogenesis of precocious osteoarthritis.
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.
Title: Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.
FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.
Title: FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.
Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.
Title: Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.
Sirtuin 3 regulates astrocyte activation by reducing Notch1 signaling after status epilepticus.
Title: Sirtuin 3 regulates astrocyte activation by reducing Notch1 signaling after status epilepticus.
SIRT3 regulates cardiolipin biosynthesis in pressure overload-induced cardiac remodeling by PPARgamma-mediated mechanism.
Title: SIRT3 regulates cardiolipin biosynthesis in pressure overload-induced cardiac remodeling by PPARγ-mediated mechanism.
Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3-SOD2-mtROS signaling.
Title: Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3-SOD2-mtROS signaling.

Submit: New GeneRIF Correction See all GeneRIFs (333)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Gene trapped (1)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sirt3 (e-PCR), detects polymorphism
- UniSTS:531294

Sirt3 (e-PCR), detects polymorphism
- UniSTS:531295

AI848213 (e-PCR)
- UniSTS:179677

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent protein lysine delactylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone H3K14 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K18 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K56 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in aerobic respiration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of peptidyl-lysine acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-lysine deacetylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of catalase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ceramide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of superoxide dismutase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-3

Names: NAD-dependent deacetylase sirtuin-3; SIR2-like protein 3; SIRT3L mitochondrial; mSIR2L3; mitochondrial protein lysine deacetylase; regulatory protein SIR2 homolog 3; silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

NP_001120823.1

EC 2.3.1.286

NP_001171275.1

EC 2.3.1.286

NP_071878.2

EC 2.3.1.286

XP_006536285.1

EC 2.3.1.286

XP_006536286.1

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127351.1 → NP_001120823.1 NAD-dependent protein deacetylase sirtuin-3 isoform 1

See identical proteins and their annotated locations for NP_001120823.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an additional segment, resulting in a downstream AUG start codon, as compared to variant 3. The resulting isoform (1) is shorter at the N-terminus, as compared to isoform 2.

Source sequence(s)

AF299338, AF299339, BF681854, CT010402

Consensus CDS

CCDS21989.1

UniProtKB/TrEMBL

A0A1B0GRY5, Q4FJK3

Related

ENSMUSP00000101663.4, ENSMUST00000106048.10

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
NM_001177804.1 → NP_001171275.1 NAD-dependent protein deacetylase sirtuin-3 isoform 3

See identical proteins and their annotated locations for NP_001171275.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longer isoform (2).

Source sequence(s)

AK075861, BF681854, CB953804

UniProtKB/Swiss-Prot

B9W0A9, C6ZII7, Q8R104, Q9EPA8

Conserved Domains (1) summary

cd01408
Location:74 → 308

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
NM_022433.2 → NP_071878.2 NAD-dependent protein deacetylase sirtuin-3 isoform 1

See identical proteins and their annotated locations for NP_071878.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) has an alternate 5' exon and an additional segment, resulting in a downstream AUG start codon, as compared to variant 3. The resulting isoform (1) is shorter at the N-terminus, as compared to isoform 2.

Source sequence(s)

AF299338, BF681854, CT010402

Consensus CDS

CCDS21989.1

UniProtKB/TrEMBL

A0A1B0GRY5, Q4FJK3

Related

ENSMUSP00000026559.8, ENSMUST00000026559.14

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

140443576..140462222 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006536222.5 → XP_006536285.1 NAD-dependent protein deacetylase sirtuin-3 isoform X1

UniProtKB/TrEMBL

D3YTK6

Conserved Domains (1) summary

cl00195
Location:74 → 254

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_006536223.5 → XP_006536286.1 NAD-dependent protein deacetylase sirtuin-3 isoform X2

See identical proteins and their annotated locations for XP_006536286.1

UniProtKB/TrEMBL

D3YVQ5

Related

ENSMUSP00000114247.2, ENSMUST00000137024.8

Conserved Domains (1) summary

cl00195
Location:1 → 177

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...