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    Cyth2 cytohesin 2 [ Mus musculus (house mouse) ]

    Gene ID: 19158, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cyth2provided by MGI
    Official Full Name
    cytohesin 2provided by MGI
    Primary source
    MGI:MGI:1334255
    See related
    Ensembl:ENSMUSG00000003269 AllianceGenome:MGI:1334255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARNO; CLM2; Pscd2
    Summary
    Enables guanyl-nucleotide exchange factor activity and inositol 1,4,5 trisphosphate binding activity. Predicted to be involved in negative regulation of dendrite development. Predicted to act upstream of or within regulation of cell adhesion. Located in bicellular tight junction. Is active in glutamatergic synapse and postsynapse. Is expressed in brain and spinal cord. Orthologous to human CYTH2 (cytohesin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 32.8), CNS E14 (RPKM 32.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cyth2 in Genome Data Viewer
    Location:
    7 B3; 7 29.52 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45456058..45463857, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45806637..45814322, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39009 Neighboring gene predicted gene 5897 Neighboring gene lemur tyrosine kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E6546 Neighboring gene STARR-positive B cell enhancer ABC_E8838 Neighboring gene STARR-positive B cell enhancer ABC_E549 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 14 Neighboring gene glutamate-rich WD repeat containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol 1,4,5 trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extrinsic component of postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytohesin-2
    Names
    ARF nucleotide-binding site opener
    PH, SEC7 and coiled-coil domain-containing protein 2
    SEC7 homolog B
    mSec7-2
    pleckstrin homology, Sec7 and coiled-coil domains 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112701.2NP_001106171.1  cytohesin-2 isoform 2

      See identical proteins and their annotated locations for NP_001106171.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame short exon of 3 nt compared to variant 1. The resulting isoform (2) is shorter by 1 aa compared to isoform 1.
      Source sequence(s)
      AC149053
      Consensus CDS
      CCDS52249.1
      UniProtKB/TrEMBL
      Q5HZZ0, Q99KH2
      Related
      ENSMUSP00000103357.2, ENSMUST00000107729.10
      Conserved Domains (2) summary
      cd01252
      Location:258377
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:61243
      Sec7; Sec7 domain
    2. NM_011181.4NP_035311.1  cytohesin-2 isoform 1

      See identical proteins and their annotated locations for NP_035311.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC149053, AK045451, AK143829, BE983477, BY470655
      UniProtKB/Swiss-Prot
      E9QJX3, O89099, P63034, P97695, Q3UP39
      UniProtKB/TrEMBL
      Q5HZZ0
      Conserved Domains (2) summary
      cd01252
      Location:258378
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:61243
      Sec7; Sec7 domain

    RNA

    1. NR_175963.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149053

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45456058..45463857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152796.1XP_036008689.1  cytohesin-2 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GRB2
      Related
      ENSMUSP00000147457.2, ENSMUST00000209245.2
      Conserved Domains (2) summary
      pfam01369
      Location:61243
      Sec7; Sec7 domain
      cl17171
      Location:258270
      PH-like; Pleckstrin homology-like domain