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    Numa1 nuclear mitotic apparatus protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 101706, updated on 9-Dec-2024

    Summary

    Official Symbol
    Numa1provided by MGI
    Official Full Name
    nuclear mitotic apparatus protein 1provided by MGI
    Primary source
    MGI:MGI:2443665
    See related
    Ensembl:ENSMUSG00000066306 AllianceGenome:MGI:2443665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NuMA; 6720401E04Rik
    Summary
    Predicted to enable several functions, including disordered domain specific binding activity; dynein complex binding activity; and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; positive regulation of BMP signaling pathway; and positive regulation of keratinocyte differentiation. Located in lateral cell cortex; mitotic spindle pole; and nuclear matrix. Is expressed in several structures, including 1st branchial arch mandibular component; early embryo; facial prominence; oocyte; and telencephalon. Orthologous to human NUMA1 (nuclear mitotic apparatus protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 20.3), ovary adult (RPKM 17.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Numa1 in Genome Data Viewer
    Location:
    7 E2; 7 54.7 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101583169..101664166)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101933977..102014959)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1089 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene transmembrane O-methyltransferase Neighboring gene leucine rich repeat containing 51 Neighboring gene STARR-positive B cell enhancer ABC_E554 Neighboring gene STARR-positive B cell enhancer ABC_E8193 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061 Neighboring gene interleukin 18 binding protein Neighboring gene ring finger protein 121 Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables disordered domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynein complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule minus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule minus-end binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule plus-end binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in anastral spindle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anastral spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astral microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astral microtubule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of mitotic spindle orientation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of chromosome separation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of chromosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitotic spindle elongation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic spindle elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein localization to spindle pole body ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to spindle pole body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of metaphase plate congression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic microtubule bundle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic microtubule bundle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule bundle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule bundle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule minus-end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule minus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule plus-end ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle astral microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle astral microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle midzone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    nuclear mitotic apparatus protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403544.1NP_001390473.1  nuclear mitotic apparatus protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC167240
    2. NM_001403545.1NP_001390474.1  nuclear mitotic apparatus protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC167240
    3. NM_001403546.1NP_001390475.1  nuclear mitotic apparatus protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC167240
    4. NM_001403547.1NP_001390476.1  nuclear mitotic apparatus protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC167240
    5. NM_001403548.1NP_001390477.1  nuclear mitotic apparatus protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC167240
    6. NM_001403549.1NP_001390478.1  nuclear mitotic apparatus protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC167240
    7. NM_001403550.1NP_001390479.1  nuclear mitotic apparatus protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC167240
    8. NM_001403551.1NP_001390480.1  nuclear mitotic apparatus protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      E9Q7G0, Q80Y35
    9. NM_001403552.1NP_001390481.1  nuclear mitotic apparatus protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC167240
    10. NM_001403553.1NP_001390482.1  nuclear mitotic apparatus protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC167240
    11. NM_133947.4NP_598708.3  nuclear mitotic apparatus protein 1 isoform b

      See identical proteins and their annotated locations for NP_598708.3

      Status: VALIDATED

      Source sequence(s)
      AC167240
      Consensus CDS
      CCDS40046.1
      UniProtKB/Swiss-Prot
      E9Q7G0, Q80Y35
      Related
      ENSMUSP00000081912.6, ENSMUST00000084852.13
      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101583169..101664166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507177.4XP_006507240.1  nuclear mitotic apparatus protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006507240.1

      UniProtKB/Swiss-Prot
      E9Q7G0, Q80Y35
      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
    2. XM_036152542.1XP_036008435.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/Swiss-Prot
      E9Q7G0, Q80Y35
      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
    3. XM_036152544.1XP_036008437.1  nuclear mitotic apparatus protein 1 isoform X5

      Conserved Domains (3) summary
      TIGR02168
      Location:4621231
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22298
      Location:17741832
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
      cl41774
      Location:159
      HkD_SF; Hook domain-containing proteins superfamily
    4. XM_036152541.1XP_036008434.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/Swiss-Prot
      E9Q7G0, Q80Y35
      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins
    5. XM_006507175.4XP_006507238.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006507238.1

      Conserved Domains (1) summary
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    6. XM_036152540.1XP_036008433.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/Swiss-Prot
      E9Q7G0, Q80Y35
      Conserved Domains (4) summary
      COG1196
      Location:11171713
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:5541323
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd22224
      Location:6151
      HkD_NuMA; Hook domain found in nuclear mitotic apparatus protein (NuMA) and similar proteins
      cd22298
      Location:18521910
      NuMA_LGNBD; LGN binding domain (LGNBD) of nuclear mitotic apparatus protein (NuMA) and similar proteins