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    Polr2i polymerase (RNA) II (DNA directed) polypeptide I [ Mus musculus (house mouse) ]

    Gene ID: 69920, updated on 9-Dec-2024

    Summary

    Official Symbol
    Polr2iprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Iprovided by MGI
    Primary source
    MGI:MGI:1917170
    See related
    Ensembl:ENSMUSG00000019738 AllianceGenome:MGI:1917170
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810002B19Rik
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II; transcription initiation at RNA polymerase II promoter; and transcription-coupled nucleotide-excision repair. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Is expressed in several structures, including alimentary system; blastocyst; integumental system; nervous system; and urinary system. Orthologous to human POLR2I (RNA polymerase II subunit I). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 84.8), whole brain E14.5 (RPKM 58.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Polr2i in Genome Data Viewer
    Location:
    7 B1; 7 17.34 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29931499..29932812)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30232074..30233387)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4914 Neighboring gene predicted gene, 53356 Neighboring gene STARR-seq mESC enhancer starr_18511 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene STARR-positive B cell enhancer ABC_E6531 Neighboring gene STARR-positive B cell enhancer ABC_E6532 Neighboring gene calpain, small subunit 1 Neighboring gene STARR-seq mESC enhancer starr_18512 Neighboring gene STARR-positive B cell enhancer ABC_E4915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:31016881-31016990 Neighboring gene tubulin folding cofactor B Neighboring gene ovo like zinc finger 3 Neighboring gene WD repeat domain 62 Neighboring gene ribosomal protein S12, pseudogene 5 Neighboring gene RIKEN cDNA 1700020L13 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:31065285-31065586 Neighboring gene THAP domain containing 8, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC73656

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transcription-coupled nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerase II subunit RPB9
    Names
    DNA-directed RNA polymerase II subunit I
    RNA polymerase II 14.5 kDa subunit
    RNA polymerase II subunit B9
    RPB14.5
    NP_081535.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027259.1NP_081535.1  DNA-directed RNA polymerase II subunit RPB9

      See identical proteins and their annotated locations for NP_081535.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062812
      Consensus CDS
      CCDS21084.1
      UniProtKB/Swiss-Prot
      P60898
      Related
      ENSMUSP00000019882.10, ENSMUST00000019882.16
      Conserved Domains (2) summary
      COG1594
      Location:14125
      RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
      cd10508
      Location:74124
      Zn-ribbon_RPB9; C-terminal zinc ribbon domain of RPB9 subunit of RNA polymerase II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29931499..29932812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)