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    Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [ Mus musculus (house mouse) ]

    Gene ID: 11740, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc25a5provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5provided by MGI
    Primary source
    MGI:MGI:1353496
    See related
    Ensembl:ENSMUSG00000016319 AllianceGenome:MGI:1353496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ant2
    Summary
    This gene encodes a transmembrane domain-containing protein that localizes to the mitochondrial inner membrane. The encoded protein facilitates the exchange of ADP from the cytoplasm with ATP from the mitochondria. Pseudogenes for this gene are found on multiple chromosomes. [provided by RefSeq, May 2015]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 861.5), kidney adult (RPKM 667.1) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc25a5 in Genome Data Viewer
    Location:
    X A3.3; X 21.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36059250..36062461)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36795597..36798808)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 57674 Neighboring gene solute carrier family 25, member 43 Neighboring gene STARR-seq mESC enhancer starr_46999 Neighboring gene STARR-seq mESC enhancer starr_47000 Neighboring gene STARR-seq mESC enhancer starr_47001 Neighboring gene predicted gene, 23613 Neighboring gene STARR-seq mESC enhancer starr_47002 Neighboring gene STARR-seq mESC enhancer starr_47003 Neighboring gene mitochondrial dynamic related lncRNA Neighboring gene STARR-seq mESC enhancer starr_47006 Neighboring gene STING1 ER exit protein 1 Neighboring gene 60S ribosomal protein L39 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC101927

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adaptive thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adenine nucleotide transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial ADP transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial ADP transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial ATP transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial ATP transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrial membrane permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MMXD complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MMXD complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mitochondrial permeability transition pore complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA  

    General protein information

    Preferred Names
    ADP/ATP translocase 2
    Names
    ADP, ATP carrier protein 2
    adenine nucleotide translocase
    adenine nucleotide translocator 2, fibroblast

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007451.4NP_031477.1  ADP/ATP translocase 2

      See identical proteins and their annotated locations for NP_031477.1

      Status: REVIEWED

      Source sequence(s)
      AK003467, BY280917, BY472909
      Consensus CDS
      CCDS30062.1
      UniProtKB/Swiss-Prot
      P51881, Q61311
      UniProtKB/TrEMBL
      Q545A2
      Related
      ENSMUSP00000016463.4, ENSMUST00000016463.4
      Conserved Domains (1) summary
      PTZ00169
      Location:7296
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      36059250..36062461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)