Ppp2r5a protein phosphatase 2, regulatory subunit B', alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp2r5aprovided by MGI
Official Full Name: protein phosphatase 2, regulatory subunit B', alphaprovided by MGI
Primary source: MGI:MGI:2388479
See related: Ensembl:ENSMUSG00000026626 AllianceGenome:MGI:2388479
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PR61alpha
Summary: Predicted to enable kinase binding activity; phosphoprotein phosphatase activity; and protein phosphatase activator activity. Predicted to be involved in negative regulation of lipid kinase activity; negative regulation of protein localization to plasma membrane; and protein dephosphorylation. Located in M band and Z disc. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; liver; and neural retina. Orthologous to human PPP2R5A (protein phosphatase 2 regulatory subunit B'alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in mammary gland adult (RPKM 92.3), subcutaneous fat pad adult (RPKM 91.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 96.28 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (191084178..191129238, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (191351981..191397041, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A PP2A-B56-Centered View on Metaphase-to-Anaphase Transition in Mouse Oocyte Meiosis I.
Title: A PP2A-B56-Centered View on Metaphase-to-Anaphase Transition in Mouse Oocyte Meiosis I.
Regulatory subunit (B56alpha) of the PP (protein phosphatase) 2A holoenzyme regulates Nav1.5 activity in mouse cardiomyocytes.
Title: Protein Phosphatase 2A Regulates Cardiac Na(+) Channels.
in vivo expression of B56alpha suppressed parasympathetic regulation of heart rate and increased RyR2 phosphorylation in cardiomyocytes.
Title: Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.
Cardiomyocyte-directed overexpression of B56alpha, the main cardiac PP2A regulatory subunit, results in the dephosphorylation of myofilament proteins, increased Ca2+ sensitivity, and higher contractility.
Title: Cardiac function is regulated by B56α-mediated targeting of protein phosphatase 2A (PP2A) to contractile relevant substrates.
reversible phosphorylation of Dzip1, which is controlled by the antagonistic action of CK2 and B56-containing PP2As, has an important impact on the stability of Gli transcription factors and Hh signaling.
Title: The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1.
Elevated B56alpha/PP2A inhibits hormone-sensitive lipase and lipolysis in white adipose tissue of DIO mice.
Title: B56alpha/protein phosphatase 2A inhibits adipose lipolysis in high-fat diet-induced obese mice.
B56alpha has a role in nuclear export of the catalytic subunit of PP2A
Title: Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit.
Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia.
Title: Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_15687-15688:1013522980:1 (e-PCR)
- UniSTS:267867

R75479 (e-PCR)
- UniSTS:125549

Ppp2r5a (e-PCR), detects polymorphism
- UniSTS:527061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of lipid kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144880.4 → NP_659129.2 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

See identical proteins and their annotated locations for NP_659129.2

Status: PROVISIONAL

Source sequence(s)

AC115896, AC124664

Consensus CDS

CCDS15620.1

UniProtKB/Swiss-Prot

Q6PD03, Q8R1U7

UniProtKB/TrEMBL

Q3ULN8

Related

ENSMUSP00000070726.4, ENSMUST00000067976.9

Conserved Domains (2) summary

PLN00122
Location:351 → 466

PLN00122; serine/threonine protein phosphatase 2A; Provisional

pfam01603
Location:64 → 461

B56; Protein phosphatase 2A regulatory B subunit (B56 family)