Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Naaladl1provided by MGI
Official Full Name: N-acetylated alpha-linked acidic dipeptidase-like 1provided by MGI
Primary source: MGI:MGI:2685810
See related: Ensembl:ENSMUSG00000054999 AllianceGenome:MGI:2685810
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm964; Naaladasel
Summary: Predicted to enable exopeptidase activity; metal ion binding activity; and protein homodimerization activity. Predicted to be involved in peptide catabolic process. Predicted to be located in apical plasma membrane. Orthologous to human NAALADL1 (N-acetylated alpha-linked acidic dipeptidase like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 793.4), small intestine adult (RPKM 412.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6155811..6166019)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6105781..6115989)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

General gene information

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Markers

AU015683 (e-PCR)
- UniSTS:209412

AU015683 (e-PCR)
- UniSTS:164642

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables aminopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables carboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: aminopeptidase NAALADL1

Names: N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L

NP_001009546.1

EC 3.4.17.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009546.2 → NP_001009546.1 aminopeptidase NAALADL1

See identical proteins and their annotated locations for NP_001009546.1

Status: VALIDATED

Source sequence(s)

AC131692

Consensus CDS

CCDS29494.1

UniProtKB/Swiss-Prot

Q7M758

Related

ENSMUSP00000044231.4, ENSMUST00000044451.4

Conserved Domains (4) summary

cd02121
Location:114 → 344

PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...

cd08022
Location:350 → 592

M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen

pfam04253
Location:642 → 739

TFR_dimer; Transferrin receptor-like dimerization domain

cl14876
Location:53 → 126

Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42