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    Pkd2l2 polycystic kidney disease 2-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 53871, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pkd2l2provided by MGI
    Official Full Name
    polycystic kidney disease 2-like 2provided by MGI
    Primary source
    MGI:MGI:1858231
    See related
    Ensembl:ENSMUSG00000014503 AllianceGenome:MGI:1858231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRPP5
    Summary
    Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to be active in membrane. Is expressed in several structures, including cochlea; pancreas; reproductive system; spleen; and stomach. Orthologous to human PKD2L2 (polycystin 2 like 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.3), CNS E18 (RPKM 6.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pkd2l2 in Genome Data Viewer
    Location:
    18 B1; 18 18.62 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34541553..34575842)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34408501..34442798)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E8999 Neighboring gene SET translocation pseudogene Neighboring gene family with sequence similarity 13, member B Neighboring gene STARR-seq mESC enhancer starr_44201 Neighboring gene STARR-seq mESC enhancer starr_44203 Neighboring gene STARR-seq mESC enhancer starr_44204 Neighboring gene STARR-seq mESC enhancer starr_44205 Neighboring gene STARR-seq mESC enhancer starr_44207 Neighboring gene wingless-type MMTV integration site family, member 8A Neighboring gene STARR-positive B cell enhancer mm9_chr18:34732422-34732722 Neighboring gene NME/NM23 family member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    polycystin-2-like protein 2
    Names
    Polycystin - L2
    polycystic kidney disease 2-like 2 protein
    polycystin-2L2
    polycystin-L2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163004.1NP_001156476.1  polycystin-2-like protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC090534, AK133423, BC138717
      Consensus CDS
      CCDS29127.1
      UniProtKB/Swiss-Prot
      B2RS50, Q9JLG4
      UniProtKB/TrEMBL
      Q3V056
      Related
      ENSMUSP00000127257.2, ENSMUST00000166156.9
      Conserved Domains (1) summary
      pfam08016
      Location:76497
      PKD_channel; Polycystin cation channel
    2. NM_016927.3NP_058623.2  polycystin-2-like protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC090534, AC115305, BC138717
      Consensus CDS
      CCDS29127.1
      UniProtKB/Swiss-Prot
      B2RS50, Q9JLG4
      UniProtKB/TrEMBL
      Q3V056
      Related
      ENSMUSP00000014647.8, ENSMUST00000014647.9
      Conserved Domains (1) summary
      pfam08016
      Location:76497
      PKD_channel; Polycystin cation channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      34541553..34575842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317946.3XP_017173435.1  polycystin-2-like protein 2 isoform X3

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:28449
      PKD_channel; Polycystin cation channel
    2. XM_017317949.3XP_017173438.1  polycystin-2-like protein 2 isoform X6

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:1407
      PKD_channel; Polycystin cation channel
    3. XM_017317950.3XP_017173439.1  polycystin-2-like protein 2 isoform X6

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:1407
      PKD_channel; Polycystin cation channel
    4. XM_017317944.3XP_017173433.1  polycystin-2-like protein 2 isoform X1

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:78499
      PKD_channel; Polycystin cation channel
    5. XM_017317948.3XP_017173437.1  polycystin-2-like protein 2 isoform X5

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:78442
      PKD_channel; Polycystin cation channel
    6. XM_036161210.1XP_036017103.1  polycystin-2-like protein 2 isoform X2

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:43463
      PKD_channel; Polycystin cation channel
    7. XM_017317947.3XP_017173436.1  polycystin-2-like protein 2 isoform X3

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:28449
      PKD_channel; Polycystin cation channel
    8. XM_006526097.5XP_006526160.1  polycystin-2-like protein 2 isoform X4

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:78499
      PKD_channel; Polycystin cation channel
    9. XM_036161212.1XP_036017105.1  polycystin-2-like protein 2 isoform X7

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:79499
      PKD_channel; Polycystin cation channel
    10. XM_017317951.3XP_017173440.1  polycystin-2-like protein 2 isoform X7

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:79499
      PKD_channel; Polycystin cation channel
    11. XM_006526101.5XP_006526164.1  polycystin-2-like protein 2 isoform X7

      UniProtKB/TrEMBL
      Q3V056
      Conserved Domains (1) summary
      pfam08016
      Location:79499
      PKD_channel; Polycystin cation channel
    12. XM_006526104.4XP_006526167.1  polycystin-2-like protein 2 isoform X8

      UniProtKB/TrEMBL
      Q3UQ78
      Conserved Domains (1) summary
      pfam08016
      Location:78281
      PKD_channel; Polycystin cation channel