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    Gcm2 glial cells missing homolog 2 [ Mus musculus (house mouse) ]

    Gene ID: 107889, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gcm2provided by MGI
    Official Full Name
    glial cells missing homolog 2provided by MGI
    Primary source
    MGI:MGI:1861438
    See related
    Ensembl:ENSMUSG00000021362 AllianceGenome:MGI:1861438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcm1; Gcm-rs1; Gcm1-rs2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within glandular epithelial cell differentiation; negative regulation of epithelial cell apoptotic process; and parathyroid gland development. Located in nucleus. Is expressed in several structures, including branchial pouch; central nervous system; foregut gland primordium; genitourinary system; and gut gland. Used to study hypoparathyroidism. Human ortholog(s) of this gene implicated in familial isolated hypoparathyroidism and hyperparathyroidism. Orthologous to human GCM2 (glial cells missing transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Gcm2 in Genome Data Viewer
    Location:
    13 A3.3; 13 20.31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41254903..41264511, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41101427..41111035, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9874 Neighboring gene transmembrane protein 14C Neighboring gene male germ cell-associated kinase Neighboring gene synaptonemal complex protein 2-like Neighboring gene STARR-seq mESC enhancer starr_34300 Neighboring gene ELOVL fatty acid elongase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC130289, MGC130290

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glandular epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gliogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in intracellular phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular phosphate ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within parathyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in parathyroid gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in parathyroid gland development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    chorion-specific transcription factor GCMb
    Names
    GCM motif protein 2
    mGCMb

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008104.2NP_032130.2  chorion-specific transcription factor GCMb

      See identical proteins and their annotated locations for NP_032130.2

      Status: VALIDATED

      Source sequence(s)
      AC158538, AF081556, BG070860
      Consensus CDS
      CCDS26472.1
      UniProtKB/Swiss-Prot
      O09102, Q2TB03, Q9QWX7, Q9Z289
      UniProtKB/TrEMBL
      A0A0R4J021
      Related
      ENSMUSP00000021791.7, ENSMUST00000021791.8
      Conserved Domains (1) summary
      pfam03615
      Location:35172
      GCM; GCM motif protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      41254903..41264511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315354.1XP_017170843.1  chorion-specific transcription factor GCMb isoform X1

      UniProtKB/TrEMBL
      A0A286YD23
      Related
      ENSMUSP00000153244.2, ENSMUST00000225271.2
      Conserved Domains (1) summary
      pfam03615
      Location:35172
      GCM; GCM motif protein