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    Gmds GDP-mannose 4, 6-dehydratase [ Mus musculus (house mouse) ]

    Gene ID: 218138, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gmdsprovided by MGI
    Official Full Name
    GDP-mannose 4, 6-dehydrataseprovided by MGI
    Primary source
    MGI:MGI:1891112
    See related
    Ensembl:ENSMUSG00000038372 AllianceGenome:MGI:1891112
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables GDP-mannose 4,6-dehydratase activity. Predicted to be involved in 'de novo' GDP-L-fucose biosynthetic process and Notch signaling pathway. Is active in cytosol. Is expressed in several structures, including alimentary system; ear; nervous system; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 98.5), colon adult (RPKM 91.5) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gmds in Genome Data Viewer
    Location:
    13 A3.2; 13 13.52 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (32003566..32522744, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (31819583..32338762, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34088 Neighboring gene predicted gene 11379 Neighboring gene forkhead box C1 Neighboring gene STARR-seq mESC enhancer starr_34090 Neighboring gene 60S ribosomal protein L17-like Neighboring gene predicted gene, 52056 Neighboring gene predicted gene, 35732 Neighboring gene STARR-seq mESC enhancer starr_34094 Neighboring gene STARR-seq mESC enhancer starr_34095 Neighboring gene predicted gene, 35672 Neighboring gene STARR-seq mESC enhancer starr_34096 Neighboring gene predicted gene, 52055 Neighboring gene STARR-seq mESC enhancer starr_34097 Neighboring gene STARR-seq mESC enhancer starr_34099 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:32430680-32430789 Neighboring gene STARR-seq mESC enhancer starr_34100 Neighboring gene predicted gene 11381 Neighboring gene STARR-seq mESC enhancer starr_34101 Neighboring gene predicted gene, 40876

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3. Kizuka Y, et al. Cell Chem Biol, 2017 Dec 21. PMID 29033318
    2. Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development. Xu J, et al. Front Cell Dev Biol, 2021. PMID 33898467, Free PMC Article
    3. Endothelial Cyp26b1 restrains murine heart valve growth during development. Ahuja N, et al. Dev Biol, 2022 Jun. PMID 35364055
    4. Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. Sullivan FX, et al. J Biol Chem, 1998 Apr 3. PMID 9525924
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18773, MGC103045

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-mannose 4,6-dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-mannose 4,6-dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-mannose 4,6-dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables GDP-mannose 4,6-dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NADP+ binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADP+ binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' GDP-L-fucose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' GDP-L-fucose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in 'de novo' GDP-L-fucose biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in GDP-mannose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP-mannose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GDP-mannose 4,6 dehydratase
    Names
    GDP-D-mannose dehydratase
    GMD
    NP_666153.1
    XP_006516719.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146041.2 → NP_666153.1  GDP-mannose 4,6 dehydratase

      See identical proteins and their annotated locations for NP_666153.1

      Status: PROVISIONAL

      Source sequence(s)
      AL645643, AL645664, AL645697, AL645763, AL645783
      Consensus CDS
      CCDS26426.1
      UniProtKB/Swiss-Prot
      Q8K0C9
      Related
      ENSMUSP00000036696.8, ENSMUST00000041859.9
      Conserved Domains (2) summary
      TIGR01472
      Location:24 → 366
      gmd; GDP-mannose 4,6-dehydratase
      pfam16363
      Location:27 → 358
      GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      32003566..32522744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516656.4 → XP_006516719.1  GDP-mannose 4,6 dehydratase isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:34 → 285
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0C9.1 GenPept UniProtKB/Swiss-Prot:Q8K0C9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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