Xaf1 XIAP associated factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Xaf1provided by MGI
Official Full Name: XIAP associated factor 1provided by MGI
Primary source: MGI:MGI:3772572
See related: Ensembl:ENSMUSG00000040483 AllianceGenome:MGI:3772572
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbox39
Summary: Predicted to enable molecular sequestering activity. Predicted to be involved in negative regulation of protein-containing complex assembly; negative regulation of type I interferon production; and response to interferon-beta. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Is expressed in embryo. Orthologous to human XAF1 (XIAP associated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: On NCBI's build 37.1 (2007), this geneID was incorrectly annotated as Fbxo39. The correct location of Fbxo39 corresponds to geneID: 628100. [03 Mar 2008]
Expression: Broad expression in lung adult (RPKM 11.5), mammary gland adult (RPKM 10.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 43.99 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (72192229..72204560)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (72301461..72313733)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
Title: XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility.
Identification of XAF1 as an endogenous AKT inhibitor.
Title: Identification of XAF1 as an endogenous AKT inhibitor.
XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7.
Title: XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7.
XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity.
Title: XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity.
XAF1 overexpression exacerbates diabetes by promoting pancreatic beta-cell apoptosis.
Title: XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis.
Macrophages activated by metabolic endotoxemia infiltrated into islets and produced IFNbeta, which induced beta-cell apoptosis by increasing the expression of Xaf1.
Title: Metabolic Endotoxemia-Activated Macrophages Promote Pancreatic β Cell Death via IFNβ-Xaf1 Pathway.
XAF1 may be a candidate tumor suppressor in neuroblastoma
Title: XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis.
XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect.
Title: XIAP-associated factor 1 (XAF1) suppresses angiogenesis in mouse endothelial cells.
Interferon gamma induces XAF1 and Noxa expression and potentiates apoptosis by STAT3 activation
Title: Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular sequestering activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: XIAP-associated factor 1

Names: BIRC4-binding protein; F-box protein 39; novel TRAF-type zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037713.4 → NP_001032802.2 XIAP-associated factor 1 isoform 1

See identical proteins and their annotated locations for NP_001032802.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK046736, AK140315, AL929071

Consensus CDS

CCDS24984.2

UniProtKB/Swiss-Prot

B7ZD14, Q3USK3, Q5NBU6, Q5NBU7, Q5NBU8, Q5NBU9

Related

ENSMUSP00000123011.2, ENSMUST00000146233.8

Conserved Domains (1) summary

PLN03086
Location:1 → 108

PLN03086; PRLI-interacting factor K; Provisional
NM_001291153.1 → NP_001278082.1 XIAP-associated factor 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two exons in the central coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK046736, AK140315, AL929071

Consensus CDS

CCDS70236.1

UniProtKB/TrEMBL

A0A6G7MAJ9

Related

ENSMUSP00000121472.3, ENSMUST00000140842.9

Conserved Domains (1) summary

PLN03086
Location:1 → 59

PLN03086; PRLI-interacting factor K; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

72192229..72204560

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314613.3 → XP_017170102.1 XIAP-associated factor 1 isoform X2

Conserved Domains (2) summary

PLN03086
Location:1 → 108

PLN03086; PRLI-interacting factor K; Provisional

pfam18608
Location:228 → 270

XAF1_C; XIAP-associated factor 1 C-terminal domain
XM_017314614.3 → XP_017170103.1 XIAP-associated factor 1 isoform X4

UniProtKB/TrEMBL

A0A6G7MA53

Conserved Domains (1) summary

PLN03086
Location:1 → 108

PLN03086; PRLI-interacting factor K; Provisional
XM_036156775.1 → XP_036012668.1 XIAP-associated factor 1 isoform X6

UniProtKB/TrEMBL

A0A6G7MAJ9

Conserved Domains (2) summary

PLN03086
Location:1 → 59

PLN03086; PRLI-interacting factor K; Provisional

pfam18608
Location:133 → 175

XAF1_C; XIAP-associated factor 1 C-terminal domain
XM_006533570.5 → XP_006533633.1 XIAP-associated factor 1 isoform X5

UniProtKB/TrEMBL

A0A6G7MA53

Conserved Domains (1) summary

PLN03086
Location:1 → 108

PLN03086; PRLI-interacting factor K; Provisional
XM_006533567.5 → XP_006533630.1 XIAP-associated factor 1 isoform X1

Conserved Domains (2) summary

PLN03086
Location:1 → 108

PLN03086; PRLI-interacting factor K; Provisional

pfam18608
Location:228 → 260

XAF1_C; XIAP-associated factor 1 C-terminal domain
XM_006533569.5 → XP_006533632.1 XIAP-associated factor 1 isoform X3

UniProtKB/TrEMBL

Z4YN17

Related

ENSMUSP00000121483.2, ENSMUST00000151440.8

Conserved Domains (2) summary

PLN03086
Location:1 → 59

PLN03086; PRLI-interacting factor K; Provisional

pfam18608
Location:133 → 165

XAF1_C; XIAP-associated factor 1 C-terminal domain
XM_011249084.4 → XP_011247386.1 XIAP-associated factor 1 isoform X7

Conserved Domains (1) summary

PLN03086
Location:1 → 108

PLN03086; PRLI-interacting factor K; Provisional