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    Mgat4e MGAT4 family, member E [ Mus musculus (house mouse) ]

    Gene ID: 71001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mgat4eprovided by MGI
    Official Full Name
    MGAT4 family, member Eprovided by MGI
    Primary source
    MGI:MGI:1918251
    See related
    Ensembl:ENSMUSG00000046367 AllianceGenome:MGI:1918251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4931440L10Rik
    Summary
    Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Orthologous to human MGAT4EP (MGAT4 family member E, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 29.3) See more
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    Genomic context

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    See Mgat4e in Genome Data Viewer
    Location:
    1 E4; 1 58.24 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134468679..134489484, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134540941..134561746, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02337 Neighboring gene tubulin alpha 5, pseudogene Neighboring gene STARR-seq mESC enhancer starr_02338 Neighboring gene predicted gene 15454 Neighboring gene STARR-positive B cell enhancer ABC_E10037 Neighboring gene predicted gene, 46159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:136456618-136456805 Neighboring gene STARR-seq mESC enhancer starr_02340 Neighboring gene predicted gene, 46160 Neighboring gene STARR-seq mESC enhancer starr_02343 Neighboring gene lysine demethylase 5B Neighboring gene STARR-seq mESC enhancer starr_02345 Neighboring gene synaptotagmin II Neighboring gene protein phosphatase 1, regulatory subunit 12B Neighboring gene predicted gene, 32670

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145300.2 → NP_001138772.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E isoform 1

      See identical proteins and their annotated locations for NP_001138772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122771
      Consensus CDS
      CCDS48370.1
      UniProtKB/Swiss-Prot
      A6H684, B7ZNB9, E9Q5L0, Q8C1J0
      Related
      ENSMUSP00000133717.2, ENSMUST00000172898.2
      Conserved Domains (1) summary
      cl04660
      Location:49 → 273
      PGAP4-like; Post-GPI attachment to proteins factor 4 and similar proteins

    2. NM_001291015.1 → NP_001277944.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E isoform 2

      See identical proteins and their annotated locations for NP_001277944.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC122771
      UniProtKB/Swiss-Prot
      A6H684
      Conserved Domains (1) summary
      pfam04666
      Location:1 → 191
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      134468679..134489484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248086.3 → XP_011246388.2  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E isoform X1

      Conserved Domains (1) summary
      pfam04666
      Location:57 → 295
      Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_183292.1: Suppressed sequence

      Description
      NM_183292.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6H684.3 GenPept UniProtKB/Swiss-Prot:A6H684

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