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    Xkr4 X-linked Kx blood group related 4 [ Mus musculus (house mouse) ]

    Gene ID: 497097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xkr4provided by MGI
    Official Full Name
    X-linked Kx blood group related 4provided by MGI
    Primary source
    MGI:MGI:3528744
    See related
    Ensembl:ENSMUSG00000051951 AllianceGenome:MGI:3528744
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XRG4; Gm210; mKIAA1889
    Summary
    Enables phospholipid scramblase activity and protein homodimerization activity. Involved in phosphatidylserine exposure on apoptotic cell surface. Located in plasma membrane. Orthologous to human XKR4 (XK related 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 4.4), frontal lobe adult (RPKM 2.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Xkr4 in Genome Data Viewer
    Location:
    1 A1; 1 1.6 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (3269956..3741733, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (3199733..3671948, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00001 Neighboring gene predicted gene, 26206 Neighboring gene STARR-seq mESC enhancer starr_00002 Neighboring gene STARR-seq mESC enhancer starr_00003 Neighboring gene coenzyme Q2 homolog, prenyltransferase pseudogene Neighboring gene predicted gene, 53491 Neighboring gene STARR-seq mESC enhancer starr_00004 Neighboring gene STARR-seq mESC enhancer starr_00005 Neighboring gene STARR-seq mESC enhancer starr_00007 Neighboring gene STARR-seq mESC enhancer starr_00008 Neighboring gene solute carrier family 35 member E3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00010 Neighboring gene predicted gene, 57489 Neighboring gene STARR-seq mESC enhancer starr_00012 Neighboring gene STARR-seq mESC enhancer starr_00013 Neighboring gene STARR-seq mESC enhancer starr_00014 Neighboring gene STARR-seq mESC enhancer starr_00015 Neighboring gene STARR-seq mESC enhancer starr_00016 Neighboring gene predicted gene, 27396 Neighboring gene STARR-seq mESC enhancer starr_00017 Neighboring gene STARR-seq mESC enhancer starr_00018 Neighboring gene STARR-seq mESC enhancer starr_00019 Neighboring gene STARR-seq mESC enhancer starr_00020 Neighboring gene STARR-seq mESC enhancer starr_00021 Neighboring gene STARR-seq mESC enhancer starr_00022 Neighboring gene STARR-seq mESC enhancer starr_00023 Neighboring gene STARR-seq mESC enhancer starr_00024 Neighboring gene STARR-seq mESC enhancer starr_00025 Neighboring gene STARR-seq mESC enhancer starr_00026 Neighboring gene STARR-seq mESC enhancer starr_00027 Neighboring gene STARR-seq mESC enhancer starr_00028 Neighboring gene STARR-seq mESC enhancer starr_00029 Neighboring gene retinitis pigmentosa 1 (human) Neighboring gene actinin alpha 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane. Maruoka M, et al. Mol Cell, 2021 Apr 1. PMID 33725486
    2. Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. Suzuki J, et al. J Biol Chem, 2014 Oct 31. PMID 25231987, Free PMC Article
    3. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    4. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.
      Title: Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.
    2. Unlike Xkr8, which is ubiquitously expressed, Xkr4 and Xkr9 expression is tissue-specific.
      Title: Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1889

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid scramblase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process involved in development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in engulfment of apoptotic cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylserine exposure on apoptotic cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylserine exposure on apoptotic cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylserine exposure on apoptotic cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    XK-related protein 4
    Names
    X Kell blood group precursor related family member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011874.1 → NP_001011874.1  XK-related protein 4

      See identical proteins and their annotated locations for NP_001011874.1

      Status: PROVISIONAL

      Source sequence(s)
      AY534250
      Consensus CDS
      CCDS14803.1
      UniProtKB/Swiss-Prot
      Q5GH67
      Related
      ENSMUSP00000070648.5, ENSMUST00000070533.5
      Conserved Domains (1) summary
      pfam09815
      Location:115 → 513
      XK-related; XK-related protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      3269956..3741733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495550.5 → XP_006495613.1  XK-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006495613.1

      UniProtKB/Swiss-Prot
      Q5GH67
      Conserved Domains (1) summary
      pfam09815
      Location:115 → 513
      XK-related; XK-related protein

    2. XM_011238395.4 → XP_011236697.1  XK-related protein 4 isoform X3

      Conserved Domains (1) summary
      pfam09815
      Location:115 → 331
      XK-related; XK-related protein

    3. XM_036152287.1 → XP_036008180.1  XK-related protein 4 isoform X2

      Conserved Domains (1) summary
      pfam09815
      Location:111 → 327
      XK-related; XK-related protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5GH67.1 GenPept UniProtKB/Swiss-Prot:Q5GH67

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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