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    PMEPA1 prostate transmembrane protein, androgen induced 1 [ Homo sapiens (human) ]

    Gene ID: 56937, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PMEPA1provided by HGNC
    Official Full Name
    prostate transmembrane protein, androgen induced 1provided by HGNC
    Primary source
    HGNC:HGNC:14107
    See related
    Ensembl:ENSG00000124225 MIM:606564; AllianceGenome:HGNC:14107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STAG1; TMEPAI
    Summary
    This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in prostate (RPKM 54.2), fat (RPKM 28.9) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PMEPA1 in Genome Data Viewer
    Location:
    20q13.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (57648396..57711472, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (59426291..59489466, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (56223452..56286528, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56143743-56144243 Neighboring gene Sharpr-MPRA regulatory region 2062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56165049-56165804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13064 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:56172128-56172301 Neighboring gene phosphoenolpyruvate carboxykinase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56193035-56193894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18167 Neighboring gene Z-DNA binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13065 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56229759-56230358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56230359-56230956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56236773-56237645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56238905-56239419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56241925-56242541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56251833-56252416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56253071-56253587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56253588-56254103 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56254668-56255192 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56255193-56255716 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18170 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56257022-56257522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56267863-56268682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56271371-56271903 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:56272784-56273983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56279768-56280362 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:56283453-56284064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56287125-56287736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56290116-56290644 Neighboring gene uncharacterized LOC105372692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56299854-56300354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56300355-56300855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56319851-56320352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56320353-56320852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56322729-56323588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56323589-56324446 Neighboring gene NF-kappaB interacting lncRNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56346807-56347450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:56347451-56348092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56358085-56358678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56369354-56369854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56410252-56410913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56410914-56411574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56474981-56475610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56475611-56476238 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:56496341-56496840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:56527975-56528475 Neighboring gene uncharacterized LOC105372693

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-β and epidermal growth factor signaling. Azami S, et al. Biochem Biophys Res Commun, 2015 Jan 9. PMID 25482449
    2. TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells. Amalia R, et al. Cell Signal, 2019 Jul. PMID 30890370
    3. PMEPA1 induces EMT via a non-canonical TGF-β signalling in colorectal cancer. Zhang L, et al. J Cell Mol Med, 2019 May. PMID 30887697, Free PMC Article
    4. PMEPA1/TMEPAI knockout impairs tumour growth and lung metastasis in MDA-MB-231 cells without changing monolayer culture cell growth. Abdelaziz M, et al. J Biochem, 2019 May 1. PMID 30873542
    5. 2-(2-nitrobenzylidene) indolin-3-one compound inhibits transmembrane prostate androgen-induced protein (TMEPAI) expression and cancer cell proliferation. Li Y, et al. Cell Prolif, 2018 Oct. PMID 30069967, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma.
      Title: CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma.
    2. METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
      Title: METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
    3. Exploring the role of PMEPA1 in gastric cancer.
      Title: Exploring the role of PMEPA1 in gastric cancer.
    4. PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer.
      Title: PMEPA1 Serves as a Prognostic Biomarker and Correlates with Immune Infiltrates in Cervical Cancer.
    5. PMEPA1 facilitates non-small cell lung cancer progression via activating the JNK signaling pathway.
      Title: PMEPA1 facilitates non-small cell lung cancer progression via activating the JNK signaling pathway.
    6. PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer.
      Title: PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer.
    7. PMEPA1 Stimulates the Proliferation, Colony Formation of Pancreatic Cancer Cells via the MAPK Signaling Pathway.
      Title: PMEPA1 Stimulates the Proliferation, Colony Formation of Pancreatic Cancer Cells via the MAPK Signaling Pathway.
    8. PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer.
      Title: PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer.
    9. Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression.
      Title: Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression.
    10. Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer.
      Title: Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of prostate transmembrane protein, androgen induced 1 (PMEPA1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef The yeast two-hybrid screen identifies the HIV-1 Nef interacting human protein prostate transmembrane protein, androgen induced 1 (PMEPA1) in cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables R-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables R-SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables WW domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein sequestering activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of SMAD protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    protein TMEPAI
    Names
    solid tumor-associated 1 protein
    solid tumor-associated gene 1
    transmembrane, prostate androgen induced RNA

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031951.1 RefSeqGene

      Range
      6522..68141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001255976.2 → NP_001242905.1  protein TMEPAI isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AF305616, AL121913, BQ008707, BU196912
      UniProtKB/TrEMBL
      Q66K30
      Related
      ENSP00000401506.1, ENST00000414037.5

    2. NM_020182.5 → NP_064567.2  protein TMEPAI isoform a

      See identical proteins and their annotated locations for NP_064567.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF305616, AL121913, BM846677, BQ008707
      Consensus CDS
      CCDS13463.1
      UniProtKB/Swiss-Prot
      Q5TDR6, Q8NER4, Q969W9, Q96B72, Q9UJD3
      UniProtKB/TrEMBL
      Q66K30
      Related
      ENSP00000345826.3, ENST00000341744.8

    3. NM_199169.3 → NP_954638.1  protein TMEPAI isoform b

      See identical proteins and their annotated locations for NP_954638.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AF224278, AF305616, AK296199, BQ008707
      Consensus CDS
      CCDS13462.1
      UniProtKB/TrEMBL
      Q5JY37, Q66K30
      Related
      ENSP00000344014.4, ENST00000347215.8

    4. NM_199170.3 → NP_954639.1  protein TMEPAI isoform c

      See identical proteins and their annotated locations for NP_954639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (c), which has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AF305616, AK296199, AY128643, BQ008707
      Consensus CDS
      CCDS13464.1
      UniProtKB/TrEMBL
      Q66K30
      Related
      ENSP00000379161.3, ENST00000395816.7
      Conserved Domains (1) summary
      cl21455
      Location:102 → 159
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_199171.3 → NP_954640.1  protein TMEPAI isoform c

      See identical proteins and their annotated locations for NP_954640.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (c), which has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AF305616, AL732104, BQ008707
      Consensus CDS
      CCDS13464.1
      UniProtKB/TrEMBL
      Q66K30
      Related
      ENSP00000265626.4, ENST00000265626.8
      Conserved Domains (1) summary
      cl21455
      Location:102 → 159
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      57648396..57711472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      59426291..59489466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q969W9.1 GenPept UniProtKB/Swiss-Prot:Q969W9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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