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    Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 19719, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rfngprovided by MGI
    Official Full Name
    RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by MGI
    Primary source
    MGI:MGI:894275
    See related
    Ensembl:ENSMUSG00000025158 AllianceGenome:MGI:894275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in regulation of Notch signaling pathway. Acts upstream of or within positive regulation of Notch signaling pathway. Predicted to be located in Golgi membrane. Is expressed in several structures, including central nervous system; genitourinary system; limb; retina; and small intestine. Orthologous to human RFNG (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 67.3), adrenal adult (RPKM 54.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rfng in Genome Data Viewer
    Location:
    11 E2; 11 84.53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120671571..120675077, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120780745..120784251, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene high mobility group AT-hook 1B Neighboring gene STARR-seq mESC enhancer starr_31367 Neighboring gene NADPH-dependent carbonyl reductase pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120637476-120637735 Neighboring gene STARR-seq mESC enhancer starr_31368 Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120657732-120657915 Neighboring gene fatty acid synthase Neighboring gene STARR-positive B cell enhancer ABC_E9039

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    beta-1,3-N-acetylglucosaminyltransferase radical fringe
    Names
    O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    radical fringe gene homolog
    NP_033079.1
    XP_006532669.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009053.2NP_033079.1  beta-1,3-N-acetylglucosaminyltransferase radical fringe

      See identical proteins and their annotated locations for NP_033079.1

      Status: VALIDATED

      Source sequence(s)
      BC066023
      Consensus CDS
      CCDS25757.1
      UniProtKB/Swiss-Prot
      B1ATU3, O09009
      Related
      ENSMUSP00000026156.8, ENSMUST00000026156.8
      Conserved Domains (1) summary
      pfam02434
      Location:56306
      Fringe; Fringe-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120671571..120675077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532606.3XP_006532669.1  beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X1

      Conserved Domains (1) summary
      pfam02434
      Location:56249
      Fringe; Fringe-like

    RNA

    1. XR_003949362.1 RNA Sequence

    2. XR_001779932.2 RNA Sequence