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    Eif3k eukaryotic translation initiation factor 3, subunit K [ Mus musculus (house mouse) ]

    Gene ID: 73830, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eif3kprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Kprovided by MGI
    Primary source
    MGI:MGI:1921080
    See related
    Ensembl:ENSMUSG00000053565 AllianceGenome:MGI:1921080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif3s12; 1200009C21Rik
    Summary
    Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex. Is expressed in embryo. Orthologous to human EIF3K (eukaryotic translation initiation factor 3 subunit K). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 97.7), placenta adult (RPKM 93.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eif3k in Genome Data Viewer
    Location:
    7 B1; 7 16.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28670797..28681322, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28971372..28981890, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene actinin alpha 4 Neighboring gene STARR-seq mESC enhancer starr_18446 Neighboring gene predicted gene, 38978 Neighboring gene predicted gene, 51446 Neighboring gene STARR-seq mESC enhancer starr_18451 Neighboring gene STARR-positive B cell enhancer ABC_E698 Neighboring gene STARR-positive B cell enhancer ABC_E1729 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1 Neighboring gene ryanodine receptor 1, skeletal muscle Neighboring gene predicted gene, 38979

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 3 subunit K
    Names
    eIF-3 p25
    eukaryotic translation initiation factor 3, subunit 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285942.2NP_001272871.1  eukaryotic translation initiation factor 3 subunit K isoform 2

      See identical proteins and their annotated locations for NP_001272871.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC166357
      Consensus CDS
      CCDS85254.1
      UniProtKB/Swiss-Prot
      Q9DBZ5
      Related
      ENSMUSP00000146940.2, ENSMUST00000207683.2
      Conserved Domains (1) summary
      pfam10075
      Location:28156
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
    2. NM_001285943.2NP_001272872.1  eukaryotic translation initiation factor 3 subunit K isoform 3

      See identical proteins and their annotated locations for NP_001272872.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) lacks an alternate internal segment and has a longer and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC166357
      Consensus CDS
      CCDS85255.1
      UniProtKB/TrEMBL
      Q3TY56
      Related
      ENSMUSP00000147214.2, ENSMUST00000208616.2
      Conserved Domains (1) summary
      pfam10075
      Location:28156
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
    3. NM_028659.4NP_082935.1  eukaryotic translation initiation factor 3 subunit K isoform 1

      See identical proteins and their annotated locations for NP_082935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC166357
      Consensus CDS
      CCDS21062.1
      UniProtKB/Swiss-Prot
      Q58EU9, Q8K3A1, Q9DBZ5
      Related
      ENSMUSP00000066038.6, ENSMUST00000066070.7
      Conserved Domains (1) summary
      pfam10075
      Location:61189
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28670797..28681322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540392.5XP_006540455.1  eukaryotic translation initiation factor 3 subunit K isoform X1

      Conserved Domains (1) summary
      cl24019
      Location:1102
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family