Nras neuroblastoma ras oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrasprovided by MGI
Official Full Name: neuroblastoma ras oncogeneprovided by MGI
Primary source: MGI:MGI:97376
See related: Ensembl:ENSMUSG00000027852 AllianceGenome:MGI:97376
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: N-ras
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in positive regulation of angiogenesis. Acts upstream of or within several processes, including T cell receptor signaling pathway; defense response to protozoan; and positive regulation of type II interferon production. Located in membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Used to study skin melanoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 24.4), placenta adult (RPKM 18.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 45.25 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (102965643..102975230)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (103058285..103067914)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Titration of RAS alters senescent state and influences tumour initiation.
Title: Titration of RAS alters senescent state and influences tumour initiation.
NRAS[Q61R] mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model.
Title: NRAS(Q61R) mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model.
Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice.
Title: Combined HRAS and NRAS ablation induces a RASopathy phenotype in mice.
A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.
Title: A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.
RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
Title: RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis.
Title: Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis.
Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice.
Title: Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice.
Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.
Title: Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.
Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation.
Title: Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation.
Senescent bone marrow microenvironment promotes Nras-mutant leukemia.
Title: Senescent bone marrow microenvironment promotes Nras-mutant leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (80)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (12) 1 citation
Targeted (14) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC28413P1 (e-PCR)
- UniSTS:272411

GDB:177539 (e-PCR)
- UniSTS:154918

NoName (e-PCR)
- UniSTS:234792

PMC316567P2 (e-PCR)
- UniSTS:273007

PMC86690P2 (e-PCR)
- UniSTS:273545

PMC86690P3 (e-PCR)
- UniSTS:273546

AA960392 (e-PCR)
- UniSTS:159162

AV095280 (e-PCR)
- UniSTS:178903

NoName (e-PCR)
- UniSTS:224499

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Ras protein signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: GTPase NRas

Names: transforming protein N-Ras

NP_001355567.1

EC 3.6.5.2

NP_001397438.1

EC 3.6.5.2

NP_001397439.1

EC 3.6.5.2

NP_001397440.1

EC 3.6.5.2

NP_001397441.1

EC 3.6.5.2

NP_001397442.1

EC 3.6.5.2

NP_035067.2

EC 3.6.5.2

XP_006501183.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.