OAZ2 ornithine decarboxylase antizyme 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OAZ2provided by HGNC
Official Full Name: ornithine decarboxylase antizyme 2provided by HGNC
Primary source: HGNC:HGNC:8096
See related: Ensembl:ENSG00000180304 MIM:604152; AllianceGenome:HGNC:8096
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AZ2
Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Expression: Ubiquitous expression in brain (RPKM 48.0), spleen (RPKM 41.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q22.31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (64687574..64703281, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (62496796..62512500, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (64979773..64995480, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study reveals a critical role of miR-34a/OAZ2 cascade in conferring a proper cellular response to colon cancer chemotherapy
Title: miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells.
Gene expression studies have identified altered expression of ornithine decarboxylase antizyme 2 in suicide completers with a history of mood disorders.
Title: Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.
This study demomistrated that H3K4me3 modification plays an important role in up regulation of OAZ2 in prefrontal cortex.
Title: Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.
elevated ODC and low OAZ2 mRNA expression levels correlate with several unfavorable genetic and clinical features in neuroblastoma.
Title: The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.
The protein product is generated using polyamine-regulated programmed ribosomal frameshifting.
Title: A second mammalian antizyme: conservation of programmed ribosomal frameshifting.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Oaz2-ps (e-PCR), detects polymorphism
- UniSTS:531479

D8S2279 (e-PCR)
- UniSTS:473907

1830 (e-PCR)
- UniSTS:70738

RH102275 (e-PCR)
- UniSTS:96609

Oaz2 (e-PCR), detects polymorphism
- UniSTS:527466

RH41813 (e-PCR)
- UniSTS:35949

D1S1425 (e-PCR)
- UniSTS:149621

G35510 (e-PCR)
- UniSTS:44150

RH78675 (e-PCR)
- UniSTS:25530

L17971 (e-PCR)
- UniSTS:43966

D13S1639 (e-PCR)
- UniSTS:473568

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ornithine decarboxylase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase inhibitor activity	IDA Inferred from Direct Assay more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of polyamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in polyamine metabolic process	TAS Traceable Author Statement more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in viral translational frameshifting	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ornithine decarboxylase antizyme 2

Names: ODC-Az 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301302.1 → NP_001288231.1 ornithine decarboxylase antizyme 2 isoform 2

See identical proteins and their annotated locations for NP_001288231.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.

Source sequence(s)

BC035493, BG059726, BI597670, DA210449

UniProtKB/TrEMBL

Q9HD73

Conserved Domains (1) summary

pfam02100
Location:97 → 180

ODC_AZ; Ornithine decarboxylase antizyme
NM_002537.3 → NP_002528.1 ornithine decarboxylase antizyme 2 isoform 1

See identical proteins and their annotated locations for NP_002528.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC035493, BG059726, DA210449

Consensus CDS

CCDS58372.1

UniProtKB/Swiss-Prot

O95190

UniProtKB/TrEMBL

Q9HD73

Related

ENSP00000463013.1, ENST00000326005.10

Conserved Domains (1) summary

pfam02100
Location:100 → 181

ODC_AZ; Ornithine decarboxylase antizyme