DAPK2 death associated protein kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DAPK2provided by HGNC
Official Full Name: death associated protein kinase 2provided by HGNC
Primary source: HGNC:HGNC:2675
See related: Ensembl:ENSG00000035664 MIM:616567; AllianceGenome:HGNC:2675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DRP1; DRP-1
Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Expression: Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q22.31

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (63907036..64046485, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (61714186..61853651, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (64199235..64338684, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomal miR-133a-3p Derived from BMSCs Alleviates Cerebral Ischemia-Reperfusion Injury via Targeting DAPK2.
Title: Exosomal miR-133a-3p Derived from BMSCs Alleviates Cerebral Ischemia-Reperfusion Injury via Targeting DAPK2.
Cigarette smoking induces aberrant N(6)-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-kappaB pathway.
Title: Cigarette smoking induces aberrant N(6)-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-κB pathway.
14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites.
Title: 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites.
miR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2.
Title: miR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2.
The intracellular signaling pathways that lead to Ser289 phosphorylation are mutually-exclusive and different for each kinase. In addition, Ser289 phosphorylation in fact enhances DAPK1 catalytic activity, similar to the effect on DAPK2. Thus, Ser289 phosphorylation activates both DAPK1 and DAPK2, but in response to different intracellular signaling pathways.
Title: Ser289 phosphorylation activates both DAPK1 and DAPK2 but in response to different intracellular signaling pathways.
remission effect of DAPK2 on placental cell oxidative damage and apoptosis in HDCP via mTOR activation
Title: Upregulation of DAPK2 ameliorates oxidative damage and apoptosis of placental cells in hypertensive disorder complicating pregnancy by suppressing human placental microvascular endothelial cell autophagy through the mTOR signaling pathway.
study reveals a unique calmodulin-independent mechanism for DAPK2 activation, critical to its function as a novel downstream effector of AMPK in autophagy
Title: Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy.
This study suggests that miR-520g contributes to tumor progression and drug resistance by post-transcriptionally downregulating DAPK2 in patients with epithelial ovarian cancer
Title: MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression.
Thyroid hormone promotes selective autophagy via induction of DAPK2-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis.
Title: Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
miR-520h suppresses Death-associated protein kinase 2 (DAPK2) expression, as restoring DAPK2 abolished miR-520h-promoted drug resistance, and knockdown of DAPK2 mitigated cell death caused by the depletion of miR-520h.
Title: miR-520h is crucial for DAPK2 regulation and breast cancer progression.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of death-associated protein kinase 2 (DAPK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15S1018 (e-PCR), detects polymorphism
- UniSTS:22279

SHGC-150910 (e-PCR)
- UniSTS:173587

GDB:434012 (e-PCR)
- UniSTS:157204

G59152 (e-PCR)
- UniSTS:136470

D11S2560 (e-PCR)
- UniSTS:37928

D15S644 (e-PCR)
- UniSTS:33880

NoName (e-PCR)
- UniSTS:482668

D15S1477 (e-PCR)
- UniSTS:474482

D15S1229 (e-PCR)
- UniSTS:71287

D15S993 (e-PCR), detects polymorphism
- UniSTS:11156

G09463 (e-PCR)
- UniSTS:52176

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of eosinophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of autophagy	TAS Traceable Author Statement more info	PubMed
involved_in regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in autophagosome lumen	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: death-associated protein kinase 2

Names: DAP kinase 2

NP_001350659.1

EC 2.7.11.1

NP_001371926.1

EC 2.7.11.1

NP_001371927.1

EC 2.7.11.1

NP_001371928.1

EC 2.7.11.1

NP_001371929.1

EC 2.7.11.1

NP_001382208.1

EC 2.7.11.1

NP_001382210.1

EC 2.7.11.1

NP_001382211.1

EC 2.7.11.1

NP_001382212.1

EC 2.7.11.1

NP_001382213.1

EC 2.7.11.1

NP_001382214.1

EC 2.7.11.1

NP_001382215.1

EC 2.7.11.1

NP_001382216.1

EC 2.7.11.1

NP_001382217.1

EC 2.7.11.1

NP_001382218.1

EC 2.7.11.1

NP_001382219.1

EC 2.7.11.1

NP_001382220.1

EC 2.7.11.1

NP_001382221.1

EC 2.7.11.1

NP_001382222.1

EC 2.7.11.1

NP_055141.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363730.2 → NP_001350659.1 death-associated protein kinase 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC015914, AC021541, GU056176

Consensus CDS

CCDS86463.1

Related

ENSP00000484390.1, ENST00000612884.4

Conserved Domains (1) summary

cd14196
Location:17 → 285

STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
NM_001384997.1 → NP_001371926.1 death-associated protein kinase 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cd14196
Location:17 → 285

STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
NM_001384998.1 → NP_001371927.1 death-associated protein kinase 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cl21453
Location:17 → 279

PKc_like; Protein Kinases, catalytic domain
NM_001384999.1 → NP_001371928.1 death-associated protein kinase 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cl21453
Location:17 → 220

PKc_like; Protein Kinases, catalytic domain
NM_001385000.1 → NP_001371929.1 death-associated protein kinase 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cl21453
Location:1 → 130

PKc_like; Protein Kinases, catalytic domain
NM_001395279.1 → NP_001382208.1 death-associated protein kinase 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cd14196
Location:17 → 285

STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
NM_001395281.1 → NP_001382210.1 death-associated protein kinase 2 isoform 8

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cl21453
Location:1 → 130

PKc_like; Protein Kinases, catalytic domain
NM_001395282.1 → NP_001382211.1 death-associated protein kinase 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cl21453
Location:17 → 279

PKc_like; Protein Kinases, catalytic domain
NM_001395283.1 → NP_001382212.1 death-associated protein kinase 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cl21453
Location:1 → 124

PKc_like; Protein Kinases, catalytic domain
NM_001395284.1 → NP_001382213.1 death-associated protein kinase 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cl21453
Location:1 → 124

PKc_like; Protein Kinases, catalytic domain
NM_001395285.1 → NP_001382214.1 death-associated protein kinase 2 isoform 10

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cd14196
Location:17 → 285

STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
NM_001395286.1 → NP_001382215.1 death-associated protein kinase 2 isoform 11

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

UniProtKB/TrEMBL

Q1RMF4

Conserved Domains (1) summary

cl21453
Location:1 → 130

PKc_like; Protein Kinases, catalytic domain
NM_001395287.1 → NP_001382216.1 death-associated protein kinase 2 isoform 11

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

UniProtKB/TrEMBL

Q1RMF4

Conserved Domains (1) summary

cl21453
Location:1 → 130

PKc_like; Protein Kinases, catalytic domain
NM_001395288.1 → NP_001382217.1 death-associated protein kinase 2 isoform 12

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cd14196
Location:17 → 285

STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
NM_001395289.1 → NP_001382218.1 death-associated protein kinase 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cl21453
Location:1 → 124

PKc_like; Protein Kinases, catalytic domain
NM_001395290.1 → NP_001382219.1 death-associated protein kinase 2 isoform 13 precursor

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cl21453
Location:1 → 76

PKc_like; Protein Kinases, catalytic domain
NM_001395291.1 → NP_001382220.1 death-associated protein kinase 2 isoform 14

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cd14196
Location:17 → 285

STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
NM_001395292.1 → NP_001382221.1 death-associated protein kinase 2 isoform 8

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cl21453
Location:1 → 130

PKc_like; Protein Kinases, catalytic domain
NM_001395293.1 → NP_001382222.1 death-associated protein kinase 2 isoform 15

Status: VALIDATED

Source sequence(s)

AC015914, AC021541

Conserved Domains (1) summary

cd14196
Location:17 → 285

STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
NM_014326.5 → NP_055141.2 death-associated protein kinase 2 isoform 1

See identical proteins and their annotated locations for NP_055141.2

Status: VALIDATED

Source sequence(s)

AB018001, AC015914, AC021541, AF052941

Consensus CDS

CCDS10188.1

UniProtKB/Swiss-Prot

E9JGM7, O75892, Q24JS1, Q9UIK4

Related

ENSP00000408277.1, ENST00000457488.6

Conserved Domains (1) summary

cd14196
Location:17 → 285

STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

RNA

NR_169522.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC015914, AC021541
NR_169523.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC015914, AC021541
NR_169524.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC015914, AC021541
NR_172521.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC015914, AC021541