Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Rev
|
rev
|
NLP-1 interacts with CRM-1 (exportin 1), one of the cellular factors that binds to Rev and is required for Rev-mediated nuclear export of HIV-1 mRNA |
PubMed
|
|
rev
|
The central FG repeat-containing region (amino acids 213-380) of NLP-1, also known as hCG1, specifically interacts with the Rev nuclear export signal (amino acids 75-83) |
PubMed
|
Vpr
|
vpr
|
HIV-1 (NL43) Vpr K27M mutant demonstrates decreased or absent TNF production from MT4C5 cells suggesting that hCG1-Vpr interaction affects TNF production from HIV-1 infected cells |
PubMed
|
|
vpr
|
HIV-1 Vpr L23F and K27M mutants are specifically altered for their binding to hCG1 |
PubMed
|
|
vpr
|
Nucleoporin CG1 (hCG1; nucleoporin-like protein 1; NLP-1) interacts with HIV-1 Vpr to mediate the docking of Vpr at the nuclear envelope which may contribute to the disruption of the nuclear envelope and to the nuclear import of viral DNA by Vpr |
PubMed
|
Go to the HIV-1, Human Interaction Database