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    Ak5 adenylate kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 229949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ak5provided by MGI
    Official Full Name
    adenylate kinase 5provided by MGI
    Primary source
    MGI:MGI:2677491
    See related
    Ensembl:ENSMUSG00000039058 AllianceGenome:MGI:2677491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in ATP metabolic process; nucleoside monophosphate phosphorylation; and phosphorylation. Predicted to be located in centriolar satellite. Predicted to be active in cytosol. Is expressed in alimentary system; cranium; nervous system; and urinary system. Orthologous to human AK5 (adenylate kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 13.7), cortex adult (RPKM 12.2) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ak5 in Genome Data Viewer
    Location:
    3 H3; 3 77.16 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152168461..152373992, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152462815..152668406, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 33 Neighboring gene zinc finger, ZZ domain containing 3 Neighboring gene predicted gene, 57837 Neighboring gene RIKEN cDNA 3110067G11 gene Neighboring gene STARR-positive B cell enhancer ABC_E4606 Neighboring gene expressed sequence AI115009 Neighboring gene STARR-seq mESC enhancer starr_09298 Neighboring gene STARR-positive B cell enhancer ABC_E9232 Neighboring gene predicted gene, 32085 Neighboring gene STARR-positive B cell enhancer ABC_E6147 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class K Neighboring gene predicted gene, 40181

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. Dzeja P, et al. Int J Mol Sci, 2009 Apr 17. PMID 19468337, Free PMC Article
    2. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
    3. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211
    4. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Angrand PO, et al. Mol Cell Proteomics, 2006 Dec. PMID 16959763
    5. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase isoenzyme 5
    Names
    ATP-AMP transphosphorylase 5
    NP_001074746.1
    NP_001342564.1
    NP_001396656.1
    NP_001396658.1
    NP_001396668.1
    NP_001396669.1
    NP_001396670.1
    NP_001396671.1
    NP_001396672.1
    NP_001396673.1
    NP_001396674.1
    NP_001396675.1
    XP_006501503.1
    XP_011238417.1
    XP_036018982.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081277.3 → NP_001074746.1  adenylate kinase isoenzyme 5 isoform 1

      See identical proteins and their annotated locations for NP_001074746.1

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720
      Consensus CDS
      CCDS38675.1
      UniProtKB/Swiss-Prot
      Q920P5
      Related
      ENSMUSP00000042785.7, ENSMUST00000045262.11
      Conserved Domains (2) summary
      TIGR01360
      Location:374 → 561
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:378 → 550
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    2. NM_001355635.2 → NP_001342564.1  adenylate kinase isoenzyme 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720
      Conserved Domains (1) summary
      cd01428
      Location:134 → 307
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    3. NM_001409727.1 → NP_001396656.1  adenylate kinase isoenzyme 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720

    4. NM_001409729.1 → NP_001396658.1  adenylate kinase isoenzyme 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720

    5. NM_001409739.1 → NP_001396668.1  adenylate kinase isoenzyme 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720

    6. NM_001409740.1 → NP_001396669.1  adenylate kinase isoenzyme 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720

    7. NM_001409741.1 → NP_001396670.1  adenylate kinase isoenzyme 5 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720

    8. NM_001409742.1 → NP_001396671.1  adenylate kinase isoenzyme 5 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720

    9. NM_001409743.1 → NP_001396672.1  adenylate kinase isoenzyme 5 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720

    10. NM_001409744.1 → NP_001396673.1  adenylate kinase isoenzyme 5 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720

    11. NM_001409745.1 → NP_001396674.1  adenylate kinase isoenzyme 5 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720

    12. NM_001409746.1 → NP_001396675.1  adenylate kinase isoenzyme 5 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC111139, AC116720

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      152168461..152373992 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163089.1 → XP_036018982.1  adenylate kinase isoenzyme 5 isoform X3

      Conserved Domains (2) summary
      TIGR01360
      Location:374 → 501
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:134 → 307
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    2. XM_011240115.4 → XP_011238417.1  adenylate kinase isoenzyme 5 isoform X1

      Conserved Domains (2) summary
      TIGR01360
      Location:374 → 540
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:134 → 307
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    3. XM_006501440.5 → XP_006501503.1  adenylate kinase isoenzyme 5 isoform X2

      Conserved Domains (2) summary
      TIGR01360
      Location:374 → 540
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:134 → 307
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920P5.2 GenPept UniProtKB/Swiss-Prot:Q920P5

    Gene LinkOut

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