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    Faxc failed axon connections homolog [ Mus musculus (house mouse) ]

    Gene ID: 76132, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Faxcprovided by MGI
    Official Full Name
    failed axon connections homologprovided by MGI
    Primary source
    MGI:MGI:1923382
    See related
    Ensembl:ENSMUSG00000028246 AllianceGenome:MGI:1923382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6230409E13Rik
    Summary
    Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human FAXC (failed axon connections homolog, metaxin like GST domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 2.9), whole brain E14.5 (RPKM 2.5) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Faxc in Genome Data Viewer
    Location:
    4 A3; 4 9.2 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21930906..22001461)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21930906..22001461)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene STARR-seq mESC enhancer starr_09734 Neighboring gene PNN interacting serine/arginine-rich Neighboring gene coenzyme Q3 methyltransferase Neighboring gene STARR-seq mESC enhancer starr_09735 Neighboring gene STARR-seq mESC enhancer starr_09736 Neighboring gene WEE1 homolog 2 pseudogene Neighboring gene predicted gene, 42260

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    failed axon connections homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175234.4 → NP_780443.2  failed axon connections homolog

      See identical proteins and their annotated locations for NP_780443.2

      Status: VALIDATED

      Source sequence(s)
      AL772187, AL772278
      Consensus CDS
      CCDS51130.1
      UniProtKB/Swiss-Prot
      Q3UMF9
      Related
      ENSMUSP00000029908.8, ENSMUST00000029908.8
      Conserved Domains (2) summary
      cd03193
      Location:187 → 327
      GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
      cd03080
      Location:99 → 172
      GST_N_Metaxin_like; GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      21930906..22001461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538340.4 → XP_006538403.1  failed axon connections homolog isoform X1

      Conserved Domains (2) summary
      pfam17171
      Location:142 → 205
      GST_C_6; Glutathione S-transferase, C-terminal domain
      pfam17172
      Location:2 → 91
      GST_N_4; Glutathione S-transferase N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UMF9.1 GenPept UniProtKB/Swiss-Prot:Q3UMF9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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