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    Camkv CaM kinase-like vesicle-associated [ Mus musculus (house mouse) ]

    Gene ID: 235604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Camkvprovided by MGI
    Official Full Name
    CaM kinase-like vesicle-associatedprovided by MGI
    Primary source
    MGI:MGI:2384296
    See related
    Ensembl:ENSMUSG00000032936 AllianceGenome:MGI:2384296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1G5
    Summary
    Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Involved in modulation of chemical synaptic transmission and regulation of modification of postsynaptic structure. Is active in glutamatergic synapse. Is expressed in brain; phalanx; and spinal cord. Orthologous to human CAMKV (CaM kinase like vesicle associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 94.6), frontal lobe adult (RPKM 87.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Camkv in Genome Data Viewer
    Location:
    9 F1; 9 59.07 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107813097..107826882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107935851..107949691)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene macrophage stimulating 1 receptor (c-met-related tyrosine kinase) Neighboring gene actin-like 11 Neighboring gene TRAF-interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E3858 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107878063-107878250 Neighboring gene STARR-positive B cell enhancer ABC_E2913 Neighboring gene ubiquitin-like modifier activating enzyme 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Liang Z, et al. Nat Commun, 2016 Oct 31. PMID 27796283, Free PMC Article
    2. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
    3. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Angrand PO, et al. Mol Cell Proteomics, 2006 Dec. PMID 16959763
    4. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
    5. Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Vanderweyde T, et al. Cell Rep, 2016 May 17. PMID 27160897, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Camkv has a role in activity-dependent maintenance of dendritic spines
      Title: The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28873, MGC118008

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    caM kinase-like vesicle-associated protein
    Names
    vesicle-associated calmodulin-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409937.1 → NP_001396866.1  caM kinase-like vesicle-associated protein

      Status: VALIDATED

      Source sequence(s)
      AL731808
      UniProtKB/Swiss-Prot
      Q3UHL1, Q8VD20
      UniProtKB/TrEMBL
      A0A0A6YW88

    2. NM_145621.3 → NP_663596.1  caM kinase-like vesicle-associated protein

      See identical proteins and their annotated locations for NP_663596.1

      Status: VALIDATED

      Source sequence(s)
      AL731808
      Consensus CDS
      CCDS40763.1
      UniProtKB/Swiss-Prot
      Q3UHL1, Q8VD20
      UniProtKB/TrEMBL
      A0A0A6YW88
      Related
      ENSMUSP00000040430.9, ENSMUST00000035700.14
      Conserved Domains (2) summary
      cd14088
      Location:22 → 286
      STKc_CaMK_like; Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases
      pfam17823
      Location:397 → 511
      DUF5585; Family of unknown function (DUF5585)

    RNA

    1. NR_176921.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL731808

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107813097..107826882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHL1.2 GenPept UniProtKB/Swiss-Prot:Q3UHL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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