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    FBRSL1 fibrosin like 1 [ Homo sapiens (human) ]

    Gene ID: 57666, updated on 3-Dec-2024

    Summary

    Official Symbol
    FBRSL1provided by HGNC
    Official Full Name
    fibrosin like 1provided by HGNC
    Primary source
    HGNC:HGNC:29308
    See related
    Ensembl:ENSG00000112787 MIM:620123; AllianceGenome:HGNC:29308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables RNA binding activity. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Ubiquitous expression in spleen (RPKM 3.9), testis (RPKM 3.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FBRSL1 in Genome Data Viewer
    Location:
    12q24.33
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132490151..132585188)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (132540214..132635194)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133066737..133161774)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133042035-133042599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133056253-133056754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133056755-133057254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7379 Neighboring gene mucin 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7380 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133067825-133068388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7381 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133114629-133115130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133115131-133115630 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:133127278-133127491 Neighboring gene uncharacterized LOC124903061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7384 Neighboring gene microRNA 6763 Neighboring gene uncharacterized LOC124903062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7385 Neighboring gene uncharacterized LOC105370094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133177517-133178052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133178053-133178587

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    fibrosin-1-like protein
    Names
    AUTS2-like protein
    HBV X-transactivated gene 9 protein
    HBV XAg-transactivated protein 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142641.2NP_001136113.1  fibrosin-1-like protein isoform 1

      See identical proteins and their annotated locations for NP_001136113.1

      Status: VALIDATED

      Source sequence(s)
      AB046765, AC079031, AC131212, BU616646
      Consensus CDS
      CCDS45010.1
      UniProtKB/Swiss-Prot
      Q86XQ1, Q9HCM7
      UniProtKB/TrEMBL
      A0A3B3IRR3
      Related
      ENSP00000396160.2, ENST00000434748.2
      Conserved Domains (1) summary
      pfam15336
      Location:587791
      Auts2; Autism susceptibility gene 2 protein
    2. NM_001367871.1NP_001354800.1  fibrosin-1-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC079031, AC131212
      Consensus CDS
      CCDS91782.1
      UniProtKB/TrEMBL
      A0A3B3IRR3, A0A7P0Z485
      Related
      ENSP00000505341.1, ENST00000680143.1
    3. NM_001382739.1NP_001369668.1  fibrosin-1-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC079031, AC131212
      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:562766
      Auts2; Autism susceptibility gene 2 protein
    4. NM_001382740.1NP_001369669.1  fibrosin-1-like protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC079031, AC131212
      Conserved Domains (1) summary
      pfam15336
      Location:404541
      Auts2; Autism susceptibility gene 2 protein
    5. NM_001382741.1NP_001369670.1  fibrosin-1-like protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC079031
      Conserved Domains (1) summary
      PRK10263
      Location:444511
      PRK10263; DNA translocase FtsK; Provisional
    6. NM_001382742.1NP_001369671.1  fibrosin-1-like protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC079031
      Consensus CDS
      CCDS91783.1
      UniProtKB/TrEMBL
      A0A1B0GUN3
      Related
      ENSP00000490180.1, ENST00000542061.2
      Conserved Domains (1) summary
      PRK10263
      Location:345412
      PRK10263; DNA translocase FtsK; Provisional
    7. NM_001382743.1NP_001369672.1  fibrosin-1-like protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC079031, AC131212

    RNA

    1. NR_168498.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC079031

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      132490151..132585188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534812.3XP_011533114.1  fibrosin-1-like protein isoform X15

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:505751
      Auts2; Autism susceptibility gene 2 protein
    2. XM_011534807.4XP_011533109.1  fibrosin-1-like protein isoform X7

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:563809
      Auts2; Autism susceptibility gene 2 protein
    3. XM_005266176.5XP_005266233.1  fibrosin-1-like protein isoform X11

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:544790
      Auts2; Autism susceptibility gene 2 protein
    4. XM_011534809.4XP_011533111.1  fibrosin-1-like protein isoform X13

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:542788
      Auts2; Autism susceptibility gene 2 protein
    5. XM_011534803.4XP_011533105.1  fibrosin-1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:604850
      Auts2; Autism susceptibility gene 2 protein
    6. XM_011534808.4XP_011533110.1  fibrosin-1-like protein isoform X8

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:604808
      Auts2; Autism susceptibility gene 2 protein
    7. XM_011534810.4XP_011533112.1  fibrosin-1-like protein isoform X14

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:604780
      Auts2; Autism susceptibility gene 2 protein
    8. XM_011534806.4XP_011533108.1  fibrosin-1-like protein isoform X6

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:581827
      Auts2; Autism susceptibility gene 2 protein
    9. XM_005266171.5XP_005266228.1  fibrosin-1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:585831
      Auts2; Autism susceptibility gene 2 protein
    10. XM_005266177.5XP_005266234.1  fibrosin-1-like protein isoform X12

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Related
      ENSP00000496901.1, ENST00000650108.1
      Conserved Domains (1) summary
      pfam15336
      Location:585789
      Auts2; Autism susceptibility gene 2 protein
    11. XM_005266175.5XP_005266232.1  fibrosin-1-like protein isoform X10

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:562808
      Auts2; Autism susceptibility gene 2 protein
    12. XM_005266173.5XP_005266230.1  fibrosin-1-like protein isoform X4

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:583829
      Auts2; Autism susceptibility gene 2 protein
    13. XM_011534805.4XP_011533107.1  fibrosin-1-like protein isoform X5

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:581827
      Auts2; Autism susceptibility gene 2 protein
    14. XM_047429219.1XP_047285175.1  fibrosin-1-like protein isoform X9

      UniProtKB/TrEMBL
      A0A3B3IRR3
    15. XM_011534804.4XP_011533106.1  fibrosin-1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRR3
      Conserved Domains (1) summary
      pfam15336
      Location:603849
      Auts2; Autism susceptibility gene 2 protein
    16. XM_047429220.1XP_047285176.1  fibrosin-1-like protein isoform X16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      132540214..132635194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372690.1XP_054228665.1  fibrosin-1-like protein isoform X15

      UniProtKB/TrEMBL
      A0A3B3IRR3
    2. XM_054372682.1XP_054228657.1  fibrosin-1-like protein isoform X7

      UniProtKB/TrEMBL
      A0A3B3IRR3
    3. XM_054372686.1XP_054228661.1  fibrosin-1-like protein isoform X11

      UniProtKB/TrEMBL
      A0A3B3IRR3
    4. XM_054372688.1XP_054228663.1  fibrosin-1-like protein isoform X13

      UniProtKB/TrEMBL
      A0A3B3IRR3
    5. XM_054372676.1XP_054228651.1  fibrosin-1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A3B3IRR3
    6. XM_054372683.1XP_054228658.1  fibrosin-1-like protein isoform X8

      UniProtKB/TrEMBL
      A0A3B3IRR3
    7. XM_054372689.1XP_054228664.1  fibrosin-1-like protein isoform X14

      UniProtKB/TrEMBL
      A0A3B3IRR3
    8. XM_054372681.1XP_054228656.1  fibrosin-1-like protein isoform X6

      UniProtKB/TrEMBL
      A0A3B3IRR3
    9. XM_054372678.1XP_054228653.1  fibrosin-1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRR3
    10. XM_054372687.1XP_054228662.1  fibrosin-1-like protein isoform X12

      UniProtKB/TrEMBL
      A0A3B3IRR3
    11. XM_054372685.1XP_054228660.1  fibrosin-1-like protein isoform X10

      UniProtKB/TrEMBL
      A0A3B3IRR3
    12. XM_054372679.1XP_054228654.1  fibrosin-1-like protein isoform X4

      UniProtKB/TrEMBL
      A0A3B3IRR3
    13. XM_054372680.1XP_054228655.1  fibrosin-1-like protein isoform X5

      UniProtKB/TrEMBL
      A0A3B3IRR3
    14. XM_054372684.1XP_054228659.1  fibrosin-1-like protein isoform X9

      UniProtKB/TrEMBL
      A0A3B3IRR3
    15. XM_054372677.1XP_054228652.1  fibrosin-1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRR3
    16. XM_054372691.1XP_054228666.1  fibrosin-1-like protein isoform X16