THY1 Thy-1 cell surface antigen [Homo sapiens (human)] - Gene

Summary

Official Symbol: THY1provided by HGNC
Official Full Name: Thy-1 cell surface antigenprovided by HGNC
Primary source: HGNC:HGNC:11801
See related: Ensembl:ENSG00000154096 MIM:188230; AllianceGenome:HGNC:11801
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD90; CDw90
Summary: This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression: Broad expression in brain (RPKM 87.8), kidney (RPKM 58.0) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q23.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (119415476..119424985, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (119437019..119446528, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (119286186..119295695, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High Expression of THY1 in Intestinal Gastric Cancer as a Key Factor in Tumor Biology: A Poor Prognosis-Independent Marker Related to the Epithelial-Mesenchymal Transition Profile.
Title: High Expression of THY1 in Intestinal Gastric Cancer as a Key Factor in Tumor Biology: A Poor Prognosis-Independent Marker Related to the Epithelial-Mesenchymal Transition Profile.
CD44, CD90 and CD96 expression in immune thrombocytopenia purpura (ITP) patients.
Title: CD44, CD90 and CD96 expression in immune thrombocytopenia purpura (ITP) patients.
Integrative analysis implicates the significance of m6A in the liver fibrosis of biliary atresia by regulating THY1.
Title: Integrative analysis implicates the significance of m6A in the liver fibrosis of biliary atresia by regulating THY1.
Circulating Cancer Stem Cells Expressing EpCAM/CD90 in Hepatocellular Carcinoma: A Pilot Study for Predicting Tumor Recurrence after Living Donor Liver Transplantation.
Title: Circulating Cancer Stem Cells Expressing EpCAM/CD90 in Hepatocellular Carcinoma: A Pilot Study for Predicting Tumor Recurrence after Living Donor Liver Transplantation.
Innovative finding of 266-nm laser regulating CD90 levels in SDSCs.
Title: Innovative finding of 266-nm laser regulating CD90 levels in SDSCs.
The mRNA Distribution of Cancer Stem Cell Marker CD90/Thy-1 Is Comparable in Hepatocellular Carcinoma of Eastern and Western Populations.
Title: The mRNA Distribution of Cancer Stem Cell Marker CD90/Thy-1 Is Comparable in Hepatocellular Carcinoma of Eastern and Western Populations.
X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma.
Title: X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma.
CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation.
Title: CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation.
Transcription factor YY1 inhibits the expression of THY1 to promote interstitial pulmonary fibrosis by activating the HSF1/miR-214 axis.
Title: Transcription factor YY1 inhibits the expression of THY1 to promote interstitial pulmonary fibrosis by activating the HSF1/miR-214 axis.
Neutrophils induced breast cancer epithelial-mesenchymal transition (EMT) via TIMP-1. Reciprocally, breast cancer cells undergoing EMT enhanced neutrophils' TIMP-1 secretion by CD90 in a cell-contact manner. In vivo, TIMP-1 neutralization or CD90 blockade significantly reduced metastasis. More importantly, TIMP-1 and CD90 were positively correlated in breast cancer and associated with poor prognosis of patients.
Title: Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop.

Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV Gag proteins adopt a ring-like supramolecular organization at sites of intercellular contacts and co-localize with CD63 tetraspanin and raft components GM1, Thy-1, and CD59	PubMed
	gag	The Matrix protein of HIV-1 Gag co-localizes with Thy-1 in lipid rafts, the site of virus particle budding from cells, and Thy-1 is incorporated into virus particles as a result of this process	PubMed
matrix	gag	HIV-1 Matrix co-localizes with Thy-1 in lipid rafts, the site of virus particle budding from cells, and Thy-1 is incorporated into virus particles as a result of this process	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH11662 (e-PCR)
- UniSTS:47254

THY1 (e-PCR)
- UniSTS:11448

SHGC-8027 (e-PCR)
- UniSTS:12475

RH15909 (e-PCR)
- UniSTS:18921

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GPI anchor binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell signaling	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection regeneration	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cellular extravasation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of focal adhesion assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rho-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal cone cell development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axolemma	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in focal adhesion	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	NAS Non-traceable Author Statement more info	PubMed
located_in neuronal cell body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thy-1 membrane glycoprotein

Names: Thy-1 T-cell antigen; thy-1 antigen

NP_001298089.1

EC 3.1.26.4

NP_001298091.1

EC 3.1.26.4

NP_001358979.1

EC 3.1.26.4

NP_006279.2

EC 3.1.26.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.