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    EIF3F eukaryotic translation initiation factor 3 subunit F [ Homo sapiens (human) ]

    Gene ID: 8665, updated on 27-Nov-2024

    Summary

    Official Symbol
    EIF3Fprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Fprovided by HGNC
    Primary source
    HGNC:HGNC:3275
    See related
    Ensembl:ENSG00000175390 MIM:603914; AllianceGenome:HGNC:3275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRT67; EIF3S5; eIF3-p47
    Summary
    Enables identical protein binding activity and metal-dependent deubiquitinase activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive intellectual developmental disorder 67. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 140.6), lymph node (RPKM 83.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See EIF3F in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (7987337..8001852)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (8066510..8081027)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (8008884..8023399)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NLR family pyrin domain containing 10 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:8008582-8009121 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:8009122-8009660 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:8016231-8017430 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3112 Neighboring gene cancer susceptibility 23 Neighboring gene uncharacterized LOC124902627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:8057222-8057786 Neighboring gene TUB bipartite transcription factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit F (EIF3F) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit F (EIF3F) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 3 subunit F
    Names
    deubiquitinating enzyme eIF3f
    eIF-3-epsilon
    eIF3-epsilon
    eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD)
    eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa
    NP_003745.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003754.3NP_003745.1  eukaryotic translation initiation factor 3 subunit F

      See identical proteins and their annotated locations for NP_003745.1

      Status: VALIDATED

      Source sequence(s)
      AC116456, BC000490, CB141463, CD050033, U94855
      Consensus CDS
      CCDS7785.1
      UniProtKB/Swiss-Prot
      A8K0S2, O00303, Q6IB45, Q8N978
      UniProtKB/TrEMBL
      B3KSH1
      Related
      ENSP00000499218.1, ENST00000651655.1
      Conserved Domains (1) summary
      cd08064
      Location:92354
      MPN_eIF3f; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      7987337..8001852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      8066510..8081027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)