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    PATL1 PAT1 homolog 1, processing body mRNA decay factor [ Homo sapiens (human) ]

    Gene ID: 219988, updated on 10-Dec-2024

    Summary

    Official Symbol
    PATL1provided by HGNC
    Official Full Name
    PAT1 homolog 1, processing body mRNA decay factorprovided by HGNC
    Primary source
    HGNC:HGNC:26721
    See related
    Ensembl:ENSG00000166889 MIM:614660; AllianceGenome:HGNC:26721
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Pat1b; hPat1b
    Summary
    Enables poly(G) binding activity and poly(U) RNA binding activity. Involved in P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in CCR4-NOT complex; P-body; and cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 16.7), placenta (RPKM 9.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PATL1 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (59636716..59669037, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (59587649..59620355, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (59404189..59436510, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein Neighboring gene microRNA 3162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3367 Neighboring gene uncharacterized LOC101927226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3368 Neighboring gene Sharpr-MPRA regulatory region 11887 Neighboring gene PATL1 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:59447851-59448351 Neighboring gene RN7SK pseudogene 192

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ36874, MGC125671, MGC125672

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables RNA binding  
    enables RNA binding PubMed 
    enables poly(G) binding PubMed 
    enables poly(U) RNA binding PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex PubMed 
    is_active_in P-body  
    located_in P-body PubMed 
    located_in PML body  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytosol  
    located_in cytosol  
    located_in nuclear speck  

    General protein information

    Preferred Names
    protein PAT1 homolog 1
    Names
    PAT1-like protein 1
    protein PAT1 homolog b
    protein associated with topoisomerase II homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152716.3NP_689929.2  protein PAT1 homolog 1

      See identical proteins and their annotated locations for NP_689929.2

      Status: VALIDATED

      Source sequence(s)
      BC111047, DC409866
      Consensus CDS
      CCDS44613.1
      UniProtKB/Swiss-Prot
      B3KXT9, Q2TA86, Q6P166, Q86TB9, Q8N9M6, Q8NI63
      Related
      ENSP00000300146.9, ENST00000300146.10
      Conserved Domains (1) summary
      pfam09770
      Location:341613
      PAT1; Topoisomerase II-associated protein PAT1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      59636716..59669037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      59587649..59620355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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