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    BLACAT1 BLACAT1 overlapping LEMD1 locus [ Homo sapiens (human) ]

    Gene ID: 101669762, updated on 10-Dec-2024

    Summary

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    Official Symbol
    BLACAT1provided by HGNC
    Official Full Name
    BLACAT1 overlapping LEMD1 locusprovided by HGNC
    Primary source
    HGNC:HGNC:48597
    See related
    Ensembl:ENSG00000281406 MIM:615480; AllianceGenome:HGNC:48597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC00912; linc-UBC1; onco-lncRNA-30
    Expression
    Broad expression in testis (RPKM 1.3), thyroid (RPKM 1.0) and 15 other tissues See more
    Orthologs
    all
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    Genomic context

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    See BLACAT1 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205434886..205456045, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (204699223..204720386, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205404014..205425173, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kelch domain containing 8A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205319640-205320547 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 10 Neighboring gene Sharpr-MPRA regulatory region 5187 Neighboring gene Sharpr-MPRA regulatory region 658 Neighboring gene uncharacterized LOC105371698 Neighboring gene LEMD1 antisense RNA 1 Neighboring gene LEM domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205379638-205380138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:205407203-205407784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205408947-205409526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205409527-205410108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205412350-205412862 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205414397-205414908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205414909-205415420 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1740 Neighboring gene microRNA 135b Neighboring gene LEMD1 divergent transcript Neighboring gene tRNA-Lys (TTT) 8-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Urinary BLACAT1 as a non-invasive biomarker for bladder cancer. El Sharkawi FZ, et al. Mol Biol Rep, 2023 May. PMID 36939965, Free PMC Article
    2. linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer. He W, et al. Biochim Biophys Acta, 2013 Oct. PMID 23688781
    3. Long noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer. Hu Y, et al. Int J Clin Exp Pathol, 2015. PMID 25755750, Free PMC Article
    4. Long noncoding RNA linc-UBC1 promotes tumor invasion and metastasis by regulating EZH2 and repressing E-cadherin in esophageal squamous cell carcinoma. Niu G, et al. J BUON, 2018 Jan-Feb. PMID 29552776
    5. Long noncoding RNA BLACAT1 modulates ABCB1 to promote oxaliplatin resistance of gastric cancer via sponging miR-361. Wu X, et al. Biomed Pharmacother, 2018 Mar. PMID 29710482

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pathogenesis of psoriasis via miR-149-5p/AKT1axis by long noncoding RNA BLACAT1.
      Title: Pathogenesis of psoriasis via miR-149-5p/AKT1axis by long noncoding RNA BLACAT1.
    2. Urinary BLACAT1 as a non-invasive biomarker for bladder cancer.
      Title: Urinary BLACAT1 as a non-invasive biomarker for bladder cancer.
    3. Role of BLACAT1 in IL-1beta-Induced Human Articular Chondrocyte Apoptosis and Extracellular Matrix Degradation via the miR-149-5p/ HMGCR Axis.
      Title: Role of BLACAT1 in IL-1β-Induced Human Articular Chondrocyte Apoptosis and Extracellular Matrix Degradation via the miR-149-5p/ HMGCR Axis.
    4. Yin Yang 1-stimulated long noncoding RNA bladder cancer-associated transcript 1 upregulation facilitates esophageal carcinoma progression via the microRNA-5590-3p/programmed cell death-ligand 1 pathway.
      Title: Yin Yang 1-stimulated long noncoding RNA bladder cancer-associated transcript 1 upregulation facilitates esophageal carcinoma progression via the microRNA-5590-3p/programmed cell death-ligand 1 pathway.
    5. LncRNA BLACAT1 Promotes Proliferation, Migration and Invasion of Prostate Cancer Cells via Regulating miR-29a-3p/DVL3 Axis.
      Title: LncRNA BLACAT1 Promotes Proliferation, Migration and Invasion of Prostate Cancer Cells via Regulating miR-29a-3p/DVL3 Axis.
    6. Effect of lncRNA-BLACAT1 on drug resistance of non-small cell lung cancer cells in DDP chemotherapy by regulating cyclin D1 expression.
      Title: Effect of lncRNA-BLACAT1 on drug resistance of non-small cell lung cancer cells in DDP chemotherapy by regulating cyclin D1 expression.
    7. Up-regulation of long non-coding RNA BLACAT1 predicts aggressive clinicopathologic characteristics and poor prognosis of glioma.
      Title: Up-regulation of long non-coding RNA BLACAT1 predicts aggressive clinicopathologic characteristics and poor prognosis of glioma.
    8. Transcription factor ZNF703 activates linc-UBC1 to stimulate the progression of glioma.
      Title: Transcription factor ZNF703 activates linc-UBC1 to stimulate the progression of glioma.
    9. Linc-UBC1 stimulates the metastasis and progression of ovarian cancer via downregulating p53 level.
      Title: Linc-UBC1 stimulates the metastasis and progression of ovarian cancer via downregulating p53 level.
    10. Expression and Diagnostic Value of lncRNA BLACAT1 in Peripheral Blood of Patients with Acute Myeloid Leukemia.
      Title: Expression and Diagnostic Value of lncRNA BLACAT1 in Peripheral Blood of Patients with Acute Myeloid Leukemia.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12532

    General protein information

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    Preferred Names
    bladder cancer associated transcript 1
    Names
    bladder cancer associated transcript 1 (non-protein coding)
    long intergenic non-protein coding RNA 912
    long intergenic noncoding RNA up-regulated in bladder cancer

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001397426.2 → NP_001384355.1  bladder cancer associated transcript 1

      Status: VALIDATED

      Source sequence(s)
      AC098936
      Consensus CDS
      CCDS91151.1
      UniProtKB/TrEMBL
      A0A494BZU2
      Related
      ENSP00000498225.1, ENST00000629624.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      205434886..205456045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421189.1 → XP_047277145.1  bladder cancer associated transcript 1 isoform X1

      UniProtKB/TrEMBL
      A0A494BZU2

    2. XM_047421190.1 → XP_047277146.1  bladder cancer associated transcript 1 isoform X1

      UniProtKB/TrEMBL
      A0A494BZU2

    3. XM_047421188.1 → XP_047277144.1  bladder cancer associated transcript 1 isoform X1

      UniProtKB/TrEMBL
      A0A494BZU2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      204699223..204720386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333731.1 → XP_054189706.1  bladder cancer associated transcript 1 isoform X1

      UniProtKB/TrEMBL
      A0A494BZU2

    2. XM_054333732.1 → XP_054189707.1  bladder cancer associated transcript 1 isoform X1

      UniProtKB/TrEMBL
      A0A494BZU2

    3. XM_054333730.1 → XP_054189705.1  bladder cancer associated transcript 1 isoform X1

      UniProtKB/TrEMBL
      A0A494BZU2
    Nucleotide Protein
    Heading Accession and Version

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