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    ZYG11A zyg-11 family member A, cell cycle regulator [ Homo sapiens (human) ]

    Gene ID: 440590, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZYG11Aprovided by HGNC
    Official Full Name
    zyg-11 family member A, cell cycle regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:32058
    See related
    Ensembl:ENSG00000203995 MIM:618675; AllianceGenome:HGNC:32058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZYG11
    Summary
    Predicted to be part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 2.3), thyroid (RPKM 1.5) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZYG11A in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52842760..52894998)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52724272..52776522)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53308432..53360670)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zyg-11 family member B, cell cycle regulator Neighboring gene ribosomal protein S13 pseudogene 2 Neighboring gene RNA, U6 small nuclear 969, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11599 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:53297677-53298444 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53301449-53302130 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53302131-53302812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53309013-53309606 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53334860-53335744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53335745-53336627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53370741-53371532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53372219-53372718 Neighboring gene Sharpr-MPRA regulatory region 4702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53377381-53377881 Neighboring gene enoyl-CoA hydratase domain containing 2 Neighboring gene translation machinery-associated protein 7-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53387115-53387797 Neighboring gene ATP synthase membrane subunit j pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease. Achlaug L, et al. Front Endocrinol (Lausanne), 2021. PMID 34220714, Free PMC Article
    2. Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells. Charoensuk C, et al. Mol Cell Endocrinol, 2021 Feb 15. PMID 33321115
    3. ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression. Wang X, et al. Oncotarget, 2016 Feb 16. PMID 26771237, Free PMC Article
    4. Meiotic human sperm cells express a leucine-rich homologue of Caenorhabditis elegans early embryogenesis gene, Zyg-11. Féral C, et al. Mol Hum Reprod, 2001 Dec. PMID 11719588, Free PMC Article
    5. The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage. Balachandran RS, et al. J Cell Biol, 2016 Oct 24. PMID 27810909, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease.
      Title: ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease.
    2. Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells.
      Title: Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells.
    3. the ubiquitin ligase CRL2(ZYG-11) redundantly targets the degradation of cyclin B1 in Caenorhabditis elegans and human cells.
      Title: The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.
    4. Over-expression of ZYG11A is associated with non-small cell lung cancer.
      Title: ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein zyg-11 homolog A
    Names
    ZYG-11A early embryogenesis protein
    zyg-11 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004339.3 → NP_001004339.2  protein zyg-11 homolog A isoform 1

      See identical proteins and their annotated locations for NP_001004339.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC099677, AI638616, AY271826, BC119815
      Consensus CDS
      CCDS44148.1
      UniProtKB/Swiss-Prot
      A6NCK5, Q6WRX3
      Related
      ENSP00000360583.1, ENST00000371528.2
      Conserved Domains (3) summary
      cd00020
      Location:511 → 629
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00116
      Location:195 → 314
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:158 → 182
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_001307931.2 → NP_001294860.1  protein zyg-11 homolog A isoform 2

      See identical proteins and their annotated locations for NP_001294860.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC099677, AI638616, AY271826, BC119815
      Consensus CDS
      CCDS76166.1
      UniProtKB/Swiss-Prot
      Q6WRX3
      Related
      ENSP00000360587.1, ENST00000371532.5
      Conserved Domains (2) summary
      cd00020
      Location:169 → 287
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cl21453
      Location:32 → 132
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      52842760..52894998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541482.4 → XP_011539784.1  protein zyg-11 homolog A isoform X3

      Conserved Domains (4) summary
      cd00020
      Location:511 → 584
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00116
      Location:195 → 314
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:158 → 182
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl21453
      Location:374 → 474
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011541480.4 → XP_011539782.1  protein zyg-11 homolog A isoform X1

      Conserved Domains (3) summary
      cd00020
      Location:511 → 614
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00116
      Location:195 → 314
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:158 → 182
      LRR_AMN1; leucine-rich repeat [structural motif]

    3. XM_011541483.4 → XP_011539785.1  protein zyg-11 homolog A isoform X4

      Conserved Domains (4) summary
      cd00020
      Location:511 → 660
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00116
      Location:195 → 314
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:158 → 182
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl21453
      Location:374 → 474
      PKc_like; Protein Kinases, catalytic domain

    4. XM_011541481.4 → XP_011539783.1  protein zyg-11 homolog A isoform X2

      Conserved Domains (3) summary
      cd00020
      Location:452 → 570
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00116
      Location:195 → 314
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:158 → 182
      LRR_AMN1; leucine-rich repeat [structural motif]

    5. XM_011541486.2 → XP_011539788.1  protein zyg-11 homolog A isoform X5

      Conserved Domains (3) summary
      cd00116
      Location:195 → 314
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:158 → 182
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl21453
      Location:374 → 474
      PKc_like; Protein Kinases, catalytic domain

    6. XM_011541487.3 → XP_011539789.1  protein zyg-11 homolog A isoform X6

      Conserved Domains (3) summary
      cd00116
      Location:195 → 314
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:158 → 182
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl21453
      Location:374 → 474
      PKc_like; Protein Kinases, catalytic domain

    7. XM_011541488.2 → XP_011539790.1  protein zyg-11 homolog A isoform X7

      Conserved Domains (2) summary
      cd00116
      Location:195 → 314
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:207 → 232
      LRR_AMN1; leucine-rich repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      52724272..52776522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336682.1 → XP_054192657.1  protein zyg-11 homolog A isoform X3

    2. XM_054336680.1 → XP_054192655.1  protein zyg-11 homolog A isoform X1

    3. XM_054336683.1 → XP_054192658.1  protein zyg-11 homolog A isoform X4

    4. XM_054336684.1 → XP_054192659.1  protein zyg-11 homolog A isoform X8

    5. XM_054336681.1 → XP_054192656.1  protein zyg-11 homolog A isoform X2

    6. XM_054336688.1 → XP_054192663.1  protein zyg-11 homolog A isoform X11

    7. XM_054336687.1 → XP_054192662.1  protein zyg-11 homolog A isoform X10

    8. XM_054336685.1 → XP_054192660.1  protein zyg-11 homolog A isoform X5

    9. XM_054336686.1 → XP_054192661.1  protein zyg-11 homolog A isoform X9

    10. XM_054336689.1 → XP_054192664.1  protein zyg-11 homolog A isoform X6

    11. XM_054336690.1 → XP_054192665.1  protein zyg-11 homolog A isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6WRX3.3 GenPept UniProtKB/Swiss-Prot:Q6WRX3

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