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    PANK3 pantothenate kinase 3 [ Homo sapiens (human) ]

    Gene ID: 79646, updated on 10-Dec-2024

    Summary

    Official Symbol
    PANK3provided by HGNC
    Official Full Name
    pantothenate kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:19365
    See related
    Ensembl:ENSG00000120137 MIM:606161; AllianceGenome:HGNC:19365
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in duodenum (RPKM 27.0), colon (RPKM 21.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PANK3 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (168548495..168579368, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (169083277..169114160, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (167975500..168006373, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83610 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83640 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83662 Neighboring gene Sharpr-MPRA regulatory region 5384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:167956617-167957158 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_83672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:167962977-167963477 Neighboring gene arginyl-tRNA synthetase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:168006261-168006804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23591 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16599 Neighboring gene solute carrier family 2 member 3 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr5:168027313-168027855 Neighboring gene microRNA 103b-1 Neighboring gene microRNA 103a-1 Neighboring gene fibrillarin like 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:168064510-168065010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:168098339-168098914 Neighboring gene ribosomal protein L10 pseudogene 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:168110883-168111382 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:168139117-168140316 Neighboring gene slit guidance ligand 3 Neighboring gene SLIT3 antisense RNA 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of pantothenate kinase 3 (PANK3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12899, MGC16863, DKFZp686O22247

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyl-CoA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pantothenate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pantothenate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pantothenate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vitamin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in coenzyme A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in coenzyme A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    pantothenate kinase 3
    Names
    hPanK3
    pantothenic acid kinase 3
    NP_078870.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024594.4NP_078870.1  pantothenate kinase 3

      See identical proteins and their annotated locations for NP_078870.1

      Status: REVIEWED

      Source sequence(s)
      AA831520, AC020894, BC013705, CB045475
      Consensus CDS
      CCDS4368.1
      UniProtKB/Swiss-Prot
      D3DQL1, Q53FJ9, Q7RTX4, Q9H999
      Related
      ENSP00000239231.6, ENST00000239231.7
      Conserved Domains (1) summary
      pfam03630
      Location:14362
      Fumble

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      168548495..168579368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      169083277..169114160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)