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    MED9 mediator complex subunit 9 [ Homo sapiens (human) ]

    Gene ID: 55090, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MED9provided by HGNC
    Official Full Name
    mediator complex subunit 9provided by HGNC
    Primary source
    HGNC:HGNC:25487
    See related
    Ensembl:ENSG00000141026 MIM:609878; AllianceGenome:HGNC:25487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MED25
    Summary
    The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 9.0), brain (RPKM 7.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MED9 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (17477000..17493221)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (17423576..17439799)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17380314..17396535)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak2757 silencer Neighboring gene ligand of numb-protein X 1, E3 ubiquitin protein ligase pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17345077-17345922 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:17349107-17350306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17353405-17353906 Neighboring gene tRNA splicing endonuclease subunit 15 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17406686-17407658 Neighboring gene ras related dexamethasone induced 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17416043-17416912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17416913-17417782 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17418653-17419522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17420393-17421262 Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene VISTA enhancer hs1917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17448679-17449178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17456297-17457102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17465957-17466820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17470469-17471358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17471359-17472250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17472251-17473140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17479915-17480660 Neighboring gene RNA, U6 small nuclear 468, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification. Franzese M, et al. Int J Mol Sci, 2024 Mar 6. PMID 38474301, Free PMC Article
    2. RNA-Seq for the identification of novel Mediator transcripts in endothelial progenitor cells. Rienzo M, et al. Gene, 2014 Aug 15. PMID 24952135
    3. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Donner AJ, et al. Nat Struct Mol Biol, 2010 Feb. PMID 20098423, Free PMC Article
    4. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. Bi W, et al. Genome Res, 2002 May. PMID 11997338, Free PMC Article
    5. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Davis MA, et al. Genes Dev, 2013 Jan 15. PMID 23322298, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification.
      Title: Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification.
    2. the FLJ10193 protein, which we designate Med25, is a bona fide subunit of the mammalian Mediator complex
      Title: A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10193, MGC138234

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 9
    Names
    mediator of RNA polymerase II transcription, subunit 9 homolog
    mediator subunit 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018019.3 → NP_060489.1  mediator of RNA polymerase II transcription subunit 9

      See identical proteins and their annotated locations for NP_060489.1

      Status: REVIEWED

      Source sequence(s)
      AC073621
      Consensus CDS
      CCDS11184.1
      UniProtKB/Swiss-Prot
      Q9NWA0
      Related
      ENSP00000268711.3, ENST00000268711.4
      Conserved Domains (1) summary
      pfam07544
      Location:64 → 139
      Med9; RNA polymerase II transcription mediator complex subunit 9

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      17477000..17493221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      17423576..17439799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWA0.1 GenPept UniProtKB/Swiss-Prot:Q9NWA0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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