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    ZDHHC6 zinc finger DHHC-type palmitoyltransferase 6 [ Homo sapiens (human) ]

    Gene ID: 64429, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZDHHC6provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 6provided by HGNC
    Primary source
    HGNC:HGNC:19160
    See related
    Ensembl:ENSG00000023041 MIM:618715; AllianceGenome:HGNC:19160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHHC6; DHHC-6; ZNF376
    Summary
    Enables palmitoyltransferase activity and protein-cysteine S-stearoyltransferase activity. Involved in positive regulation of mitochondrial fusion; protein palmitoylation; and protein stearoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in small intestine (RPKM 19.0), duodenum (RPKM 17.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZDHHC6 in Genome Data Viewer
    Location:
    10q25.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (112424412..112447572, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (113315089..113338239, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (114184170..114207330, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2832 Neighboring gene microRNA 6715b Neighboring gene microRNA 6715a Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2G, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114135606-114136106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114136107-114136607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2834 Neighboring gene acyl-CoA synthetase long chain family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4066 Neighboring gene Sharpr-MPRA regulatory region 13267 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4067 Neighboring gene uncharacterized LOC124902503 Neighboring gene microRNA 4295 Neighboring gene Sharpr-MPRA regulatory region 921 Neighboring gene Sharpr-MPRA regulatory region 3692 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:114492107-114492608 Neighboring gene Sharpr-MPRA regulatory region 7283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:114563987-114564486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114570610-114571310 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114571311-114572009 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:114572010-114572709 Neighboring gene uncharacterized LOC103344931

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21952, FLJ30429

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-cysteine S-stearoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein stearoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    palmitoyltransferase ZDHHC6
    Names
    stearoyltransferase ZDHHC6
    transmembrane protein H4
    zinc finger DHHC domain-containing protein 6
    zinc finger DHHC-type containing 6
    zinc finger protein 376
    NP_001290063.1
    NP_001338011.1
    NP_001338012.1
    NP_001338013.1
    NP_001338014.1
    NP_001338015.1
    NP_001350473.1
    NP_001397995.1
    NP_071939.1
    XP_006718012.1
    XP_011538393.1
    XP_011538395.1
    XP_011538397.1
    XP_016872051.1
    XP_016872052.1
    XP_016872053.1
    XP_016872055.1
    XP_016872056.1
    XP_016872057.1
    XP_016872058.1
    XP_047281609.1
    XP_047281610.1
    XP_047281611.1
    XP_047281613.1
    XP_047281614.1
    XP_047281615.1
    XP_047281616.1
    XP_047281617.1
    XP_054222573.1
    XP_054222574.1
    XP_054222575.1
    XP_054222576.1
    XP_054222577.1
    XP_054222578.1
    XP_054222579.1
    XP_054222580.1
    XP_054222581.1
    XP_054222582.1
    XP_054222583.1
    XP_054222584.1
    XP_054222585.1
    XP_054222586.1
    XP_054222587.1
    XP_054222588.1
    XP_054222589.1
    XP_054222590.1
    XP_054222591.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303134.2NP_001290063.1  palmitoyltransferase ZDHHC6 isoform 2

      See identical proteins and their annotated locations for NP_001290063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI695150, BC007213, BX647270, DA745043
      Consensus CDS
      CCDS76335.1
      UniProtKB/TrEMBL
      A0A804HJ80
      Related
      ENSP00000358412.3, ENST00000369404.3
      Conserved Domains (1) summary
      pfam01529
      Location:91237
      zf-DHHC; DHHC palmitoyltransferase
    2. NM_001351082.3NP_001338011.1  palmitoyltransferase ZDHHC6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AC022018, AI695150, AK025605, BX647270, DA745043, DC354896
      Consensus CDS
      CCDS7574.1
      UniProtKB/Swiss-Prot
      D3DRB6, Q53G45, Q96IV7, Q9H605, Q9H6R6
      UniProtKB/TrEMBL
      A0A804HJ80
      Conserved Domains (2) summary
      pfam01529
      Location:95241
      DHHC; DHHC palmitoyltransferase
      cl17036
      Location:317394
      SH3; Src Homology 3 domain superfamily
    3. NM_001351083.2NP_001338012.1  palmitoyltransferase ZDHHC6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AI695150, AK025605, BX647270, DA936028
      Consensus CDS
      CCDS7574.1
      UniProtKB/Swiss-Prot
      D3DRB6, Q53G45, Q96IV7, Q9H605, Q9H6R6
      UniProtKB/TrEMBL
      A0A804HJ80
      Related
      ENSP00000507661.1, ENST00000683895.1
      Conserved Domains (2) summary
      pfam01529
      Location:95241
      DHHC; DHHC palmitoyltransferase
      cl17036
      Location:317394
      SH3; Src Homology 3 domain superfamily
    4. NM_001351084.2NP_001338013.1  palmitoyltransferase ZDHHC6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AI695150, AK025605, BX647270, DA621943, DA936028
      Consensus CDS
      CCDS7574.1
      UniProtKB/Swiss-Prot
      D3DRB6, Q53G45, Q96IV7, Q9H605, Q9H6R6
      UniProtKB/TrEMBL
      A0A804HJ80
      Related
      ENSP00000507009.1, ENST00000684507.1
      Conserved Domains (2) summary
      pfam01529
      Location:95241
      DHHC; DHHC palmitoyltransferase
      cl17036
      Location:317394
      SH3; Src Homology 3 domain superfamily
    5. NM_001351085.2NP_001338014.1  palmitoyltransferase ZDHHC6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AI695150, AK025605, BP378060, BX647270, DA745043
      Conserved Domains (2) summary
      cl17036
      Location:213292
      SH3; Src Homology 3 domain superfamily
      cl19890
      Location:49137
      DHHC; DHHC palmitoyltransferase
    6. NM_001351086.2NP_001338015.1  palmitoyltransferase ZDHHC6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AI695150, AK025605, BP378060, BX647270, DA745043, DB122344
      Conserved Domains (1) summary
      cl19890
      Location:52133
      zf-DHHC; DHHC palmitoyltransferase
    7. NM_001363544.2NP_001350473.1  palmitoyltransferase ZDHHC6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC022018, AL157786
      Consensus CDS
      CCDS86144.1
      UniProtKB/TrEMBL
      A0A0D9SEX5, A0A804HL63
      Related
      ENSP00000507679.1, ENST00000682267.1
      Conserved Domains (1) summary
      pfam01529
      Location:95241
      DHHC; DHHC palmitoyltransferase
    8. NM_001411066.1NP_001397995.1  palmitoyltransferase ZDHHC6 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC022018
      Consensus CDS
      CCDS91345.1
      UniProtKB/TrEMBL
      A0A804HJ40, A0A804HJ80
    9. NM_022494.3NP_071939.1  palmitoyltransferase ZDHHC6 isoform 1

      See identical proteins and their annotated locations for NP_071939.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
      Source sequence(s)
      AI695150, AK025605, BX647270, DA745043
      Consensus CDS
      CCDS7574.1
      UniProtKB/Swiss-Prot
      D3DRB6, Q53G45, Q96IV7, Q9H605, Q9H6R6
      UniProtKB/TrEMBL
      A0A804HJ80
      Related
      ENSP00000358413.3, ENST00000369405.7
      Conserved Domains (2) summary
      pfam01529
      Location:95241
      DHHC; DHHC palmitoyltransferase
      cl17036
      Location:317394
      SH3; Src Homology 3 domain superfamily

    RNA

    1. NR_147045.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC022018, AI695150, AK025605, AW751101, BX647270, DA745043
      Related
      ENST00000684173.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      112424412..112447572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425653.1XP_047281609.1  palmitoyltransferase ZDHHC6 isoform X2

      UniProtKB/TrEMBL
      A0A0D9SEX5, A0A804HL63
    2. XM_047425660.1XP_047281616.1  palmitoyltransferase ZDHHC6 isoform X9

    3. XM_017016566.3XP_016872055.1  palmitoyltransferase ZDHHC6 isoform X3

      UniProtKB/TrEMBL
      A0A804HL63
    4. XM_047425657.1XP_047281613.1  palmitoyltransferase ZDHHC6 isoform X6

      UniProtKB/TrEMBL
      A0A804HL63
    5. XM_011540091.3XP_011538393.1  palmitoyltransferase ZDHHC6 isoform X2

      UniProtKB/TrEMBL
      A0A0D9SEX5, A0A804HL63
      Related
      ENSP00000508215.1, ENST00000683505.1
      Conserved Domains (1) summary
      pfam01529
      Location:95241
      DHHC; DHHC palmitoyltransferase
    6. XM_017016564.3XP_016872053.1  palmitoyltransferase ZDHHC6 isoform X2

      UniProtKB/TrEMBL
      A0A0D9SEX5, A0A804HL63
      Related
      ENSP00000486105.1, ENST00000626395.2
      Conserved Domains (1) summary
      pfam01529
      Location:95241
      DHHC; DHHC palmitoyltransferase
    7. XM_047425654.1XP_047281610.1  palmitoyltransferase ZDHHC6 isoform X2

      UniProtKB/TrEMBL
      A0A0D9SEX5, A0A804HL63
      Related
      ENSP00000508135.1, ENST00000682839.1
    8. XM_047425659.1XP_047281615.1  palmitoyltransferase ZDHHC6 isoform X8

    9. XM_017016563.3XP_016872052.1  palmitoyltransferase ZDHHC6 isoform X1

      UniProtKB/TrEMBL
      A0A804HJ80
      Conserved Domains (1) summary
      pfam01529
      Location:91237
      zf-DHHC; DHHC palmitoyltransferase
    10. XM_017016568.3XP_016872057.1  palmitoyltransferase ZDHHC6 isoform X8

      Conserved Domains (2) summary
      cl17036
      Location:213292
      SH3; Src Homology 3 domain superfamily
      cl19890
      Location:49137
      DHHC; DHHC palmitoyltransferase
    11. XM_017016567.3XP_016872056.1  palmitoyltransferase ZDHHC6 isoform X5

      UniProtKB/TrEMBL
      A0A804HJ80
    12. XM_011540095.4XP_011538397.1  palmitoyltransferase ZDHHC6 isoform X10

    13. XM_006717949.5XP_006718012.1  palmitoyltransferase ZDHHC6 isoform X4

      See identical proteins and their annotated locations for XP_006718012.1

      UniProtKB/TrEMBL
      A0A804HJ40, A0A804HJ80
      Related
      ENSP00000507345.1, ENST00000682195.1
      Conserved Domains (2) summary
      pfam01529
      Location:95188
      zf-DHHC; DHHC palmitoyltransferase
      cl17036
      Location:263342
      SH3; Src Homology 3 domain superfamily
    14. XM_017016562.3XP_016872051.1  palmitoyltransferase ZDHHC6 isoform X1

      UniProtKB/TrEMBL
      A0A804HJ80
      Conserved Domains (1) summary
      pfam01529
      Location:91237
      zf-DHHC; DHHC palmitoyltransferase
    15. XM_047425661.1XP_047281617.1  palmitoyltransferase ZDHHC6 isoform X10

    16. XM_011540093.3XP_011538395.1  palmitoyltransferase ZDHHC6 isoform X8

      See identical proteins and their annotated locations for XP_011538395.1

      Conserved Domains (2) summary
      cl17036
      Location:213292
      SH3; Src Homology 3 domain superfamily
      cl19890
      Location:49137
      DHHC; DHHC palmitoyltransferase
    17. XM_047425655.1XP_047281611.1  palmitoyltransferase ZDHHC6 isoform X4

      UniProtKB/TrEMBL
      A0A804HJ40, A0A804HJ80
    18. XM_017016569.2XP_016872058.1  palmitoyltransferase ZDHHC6 isoform X11

    19. XM_047425658.1XP_047281614.1  palmitoyltransferase ZDHHC6 isoform X7

    RNA

    1. XR_007061983.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      113315089..113338239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366602.1XP_054222577.1  palmitoyltransferase ZDHHC6 isoform X2

      UniProtKB/TrEMBL
      A0A0D9SEX5, A0A804HL63
    2. XM_054366613.1XP_054222588.1  palmitoyltransferase ZDHHC6 isoform X9

    3. XM_054366604.1XP_054222579.1  palmitoyltransferase ZDHHC6 isoform X3

      UniProtKB/TrEMBL
      A0A804HL63
    4. XM_054366600.1XP_054222575.1  palmitoyltransferase ZDHHC6 isoform X2

      UniProtKB/TrEMBL
      A0A0D9SEX5, A0A804HL63
    5. XM_054366601.1XP_054222576.1  palmitoyltransferase ZDHHC6 isoform X2

      UniProtKB/TrEMBL
      A0A0D9SEX5, A0A804HL63
    6. XM_054366608.1XP_054222583.1  palmitoyltransferase ZDHHC6 isoform X6

      UniProtKB/TrEMBL
      A0A804HL63
    7. XM_054366603.1XP_054222578.1  palmitoyltransferase ZDHHC6 isoform X2

      UniProtKB/TrEMBL
      A0A0D9SEX5, A0A804HL63
    8. XM_054366612.1XP_054222587.1  palmitoyltransferase ZDHHC6 isoform X8

    9. XM_054366599.1XP_054222574.1  palmitoyltransferase ZDHHC6 isoform X1

      UniProtKB/TrEMBL
      A0A804HJ80
    10. XM_054366610.1XP_054222585.1  palmitoyltransferase ZDHHC6 isoform X8

    11. XM_054366607.1XP_054222582.1  palmitoyltransferase ZDHHC6 isoform X5

      UniProtKB/TrEMBL
      A0A804HJ80
    12. XM_054366614.1XP_054222589.1  palmitoyltransferase ZDHHC6 isoform X10

    13. XM_054366605.1XP_054222580.1  palmitoyltransferase ZDHHC6 isoform X4

      UniProtKB/TrEMBL
      A0A804HJ40, A0A804HJ80
    14. XM_054366598.1XP_054222573.1  palmitoyltransferase ZDHHC6 isoform X1

      UniProtKB/TrEMBL
      A0A804HJ80
    15. XM_054366615.1XP_054222590.1  palmitoyltransferase ZDHHC6 isoform X10

    16. XM_054366611.1XP_054222586.1  palmitoyltransferase ZDHHC6 isoform X8

    17. XM_054366606.1XP_054222581.1  palmitoyltransferase ZDHHC6 isoform X4

      UniProtKB/TrEMBL
      A0A804HJ40, A0A804HJ80
    18. XM_054366616.1XP_054222591.1  palmitoyltransferase ZDHHC6 isoform X11

    19. XM_054366609.1XP_054222584.1  palmitoyltransferase ZDHHC6 isoform X7

    RNA

    1. XR_008488252.1 RNA Sequence