SIVA1 SIVA1 apoptosis inducing factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: SIVA1provided by HGNC
Official Full Name: SIVA1 apoptosis inducing factorprovided by HGNC
Primary source: HGNC:HGNC:17712
See related: Ensembl:ENSG00000184990 MIM:605567; AllianceGenome:HGNC:17712
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIVA; CD27BP; Siva-1; Siva-2
Summary: This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
Expression: Ubiquitous expression in bone marrow (RPKM 15.7), fat (RPKM 10.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q32.33

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (104753147..104759654)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (98996033..99002540)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (105219484..105225991)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo.
Title: Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo.
Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1.
Title: Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1.
N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis.
Title: N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis.
Siva1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NFkappaB pathway.
Title: Siva‑1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NF‑κB pathway.
PM2.5 exposure induces alveolar epithelial cell apoptosis and causes emphysema through p53/Siva-1.
Title: PM2.5 exposure induces alveolar epithelial cell apoptosis and causes emphysema through p53/Siva-1.
SIVA1 enhances SSBP3 ubiquitination and promotes SSBP3 protein turnover
Title: [SIVA1 Regulates the Stability of Single-Stranded DNA-Binding Protein 3 Isoforms].
Loss of SIVA1 expression is associated with nasopharyngeal carcinoma.
Title: Anticancer activity of recombinant Siva1 protein in human nasopharyngeal carcinoma cell line CNE-2.
These findings collectively reveal a novel role for the p53 target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53.
Title: The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells.
Title: Preliminary research on the expression, purification and function of the apoptotic fusion protein, Sival.
electrical stimulation -inducible SIVA1 modulates p53 activities in proliferating keratinocytes, and exogenous electrical stimulation affects p53/HDM2/SIVA1 axis leading to increased proliferation during re-epithelialization
Title: Electrical stimulation enhances epidermal proliferation in human cutaneous wounds by modulating p53-SIVA1 interaction.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of SIVA1, apoptosis-inducing factor (SIVA1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9	PubMed
Envelope transmembrane glycoprotein gp41	env	Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables CD27 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CD27 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info
enables virus receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in activation-induced cell death of T cells	IDA Inferred from Direct Assay more info	PubMed
involved_in extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: apoptosis regulatory protein Siva

Names: CD27-binding (Siva) protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029449.1 RefSeqGene

Range

5015..11522

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_006427.4 → NP_006418.2 apoptosis regulatory protein Siva isoform 1

See identical proteins and their annotated locations for NP_006418.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the predominant and longer transcript. It encodes isoform 1 and includes the apoptotic properties of Siva.

Source sequence(s)

BC034562, BU195069, CK001877

Consensus CDS

CCDS9992.1

UniProtKB/Swiss-Prot

O15304, Q96P98, Q9UPD6

UniProtKB/TrEMBL

Q53FF7

Related

ENSP00000329213.6, ENST00000329967.11

Conserved Domains (1) summary

pfam05458
Location:1 → 175

Siva; Cd27 binding protein (Siva)
NM_021709.3 → NP_068355.1 apoptosis regulatory protein Siva isoform 2

See identical proteins and their annotated locations for NP_068355.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. It appears to lack the apoptotic properties of Siva. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

BC034562, BU195069

Consensus CDS

CCDS9993.1

UniProtKB/Swiss-Prot

O15304

Related

ENSP00000329447.6, ENST00000347067.9

Conserved Domains (1) summary

pfam05458
Location:1 → 110

Siva; Cd27 binding protein (Siva)