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    Haloacid dehalogenase-like hydrolase (HAD) superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818456, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Haloacid dehalogenase-like hydrolase (HAD) superfamily protein
    Primary source
    TAIR:AT2G38740
    Locus tag
    AT2G38740
    See related
    Araport:AT2G38740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T6A23.6; T6A23_6
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (16194326..16196183, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 65-5 Neighboring gene Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein Neighboring gene annexin 4 Neighboring gene annexin 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The kinetic analysis of the substrate specificity of motif 5 in a HAD hydrolase-type phosphosugar phosphatase of Arabidopsis thaliana. Caparrós-Martín JA, et al. Planta, 2014 Sep. PMID 24915748
    2. HAD hydrolase function unveiled by substrate screening: enzymatic characterization of Arabidopsis thaliana subclass I phosphosugar phosphatase AtSgpp. Caparrós-Martín JA, et al. Planta, 2013 Apr. PMID 23179445, Free PMC Article
    3. Sequence Determinants of Substrate Ambiguity in a HAD Phosphosugar Phosphatase of Arabidopsis Thaliana. Caparrós-Martín JA, et al. Biology (Basel), 2019 Oct 9. PMID 31601035, Free PMC Article
    4. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation A69M, changes the pH dependence of AtSgpp catalysis, and mutant protein AtSgpp-H72K was inactive in phosphomonoester dephosphorylation.
      Title: The kinetic analysis of the substrate specificity of motif 5 in a HAD hydrolase-type phosphosugar phosphatase of Arabidopsis thaliana.
    2. functions in housekeeping detoxification, modulation of sugar-phosphate balance and Pi homeostasis
      Title: HAD hydrolase function unveiled by substrate screening: enzymatic characterization of Arabidopsis thaliana subclass I phosphosugar phosphatase AtSgpp.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_129431.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables sugar-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Haloacid dehalogenase-like hydrolase (HAD) superfamily protein
    NP_565895.1
    • Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; FUNCTIONS IN: hydrolase activity, catalytic activity; INVOLVED IN: metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), Haloacid dehydrogenase/epoxide hydrolase (InterPro:IPR005833), HAD-superfamily hydrolase, subfamily IA, variant 3 (InterPro:IPR006402); BEST Arabidopsis thaliana protein match is: haloacid dehalogenase-like hydrolase family protein (TAIR:AT1G56500.1); Has 17978 Blast hits to 17978 proteins in 2581 species: Archae - 265; Bacteria - 14433; Metazoa - 167; Fungi - 429; Plants - 387; Viruses - 3; Other Eukaryotes - 2294 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16194326..16196183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129431.2 → NP_565895.1  Haloacid dehalogenase-like hydrolase (HAD) superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565895.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93ZP4, Q9ZVJ5
      UniProtKB/TrEMBL
      A0A5S9X596, A0A654F042
      Conserved Domains (1) summary
      PLN02770
      Location:1 → 244
      PLN02770; haloacid dehalogenase-like hydrolase family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZVJ5.2

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