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    ACC1 acetyl-CoA carboxylase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840521, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACC1
    Official Full Name
    acetyl-CoA carboxylase 1
    Primary source
    TAIR:AT1G36160
    Locus tag
    AT1G36160
    See related
    Araport:AT1G36160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acetyl-CoA carboxylase 1; AT-ACC1; EMB22; EMBRYO DEFECTIVE 22; GK; GLOSSYHEAD 1; GSD1; GURKE; PAS3; PASTICCINO 3; SENSITIVE TO FREEZING 3; SFR3
    Summary
    Encodes acetyl-CoA carboxylase. Mutant displays uncoordinated cell divisions which are enhanced by cytokinins. Mutant also has aberrant organization of the apical region in the embryo and abnormal root and shoot development and is deficient in freezing tolerance after cold acclimation. Essential for very long chain fatty acid elongation.
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    Genomic context

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    See ACC1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    32
    Sequence:
    Chromosome: 1; NC_003070.9 (13533168..13544015)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene acetyl-CoA carboxylase 2 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sensitive to freezing3 mutation of Arabidopsis thaliana is a cold-sensitive allele of homomeric acetyl-CoA carboxylase that results in cold-induced cuticle deficiencies. Amid A, et al. J Exp Bot, 2012 Sep. PMID 22791831, Free PMC Article
    2. The glossyhead1 allele of ACC1 reveals a principal role for multidomain acetyl-coenzyme A carboxylase in the biosynthesis of cuticular waxes by Arabidopsis. Lü S, et al. Plant Physiol, 2011 Nov. PMID 21949210, Free PMC Article
    3. gurke and pasticcino3 mutants affected in embryo development are impaired in acetyl-CoA carboxylase. Baud S, et al. EMBO Rep, 2004 May. PMID 15088065, Free PMC Article
    4. Multifunctional acetyl-CoA carboxylase 1 is essential for very long chain fatty acid elongation and embryo development in Arabidopsis. Baud S, et al. Plant J, 2003 Jan. PMID 12943542
    5. The GURKE gene is required for normal organization of the apical region in the Arabidopsis embryo. Torres-Ruiz RA, et al. Plant J, 1996 Dec. PMID 9011083

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. sensitive to freezing3(sfr3) is a missense mutation in aminoglycoside N1-acetyltransferase. Freezing sensitivity of sfr3 appears to be due to cuticular deficiencies that develop during cold acclimation.
      Title: The sensitive to freezing3 mutation of Arabidopsis thaliana is a cold-sensitive allele of homomeric acetyl-CoA carboxylase that results in cold-induced cuticle deficiencies.
    2. The gsd1 locus was mapped to chromosome 1, and the causal gene was identified as a new allele of Acetyl-Coenzyme A Carboxylase1 (ACC1), a gene encoding the main enzyme in cytosolic malonyl-coenzyme A synthesis.
      Title: The glossyhead1 allele of ACC1 reveals a principal role for multidomain acetyl-coenzyme A carboxylase in the biosynthesis of cuticular waxes by Arabidopsis.
    3. Data suggest that the lack of cytosolic malonyl-CoA is likely to be the initial factor leading to abnormal development in acetyl-CoA carboxylase 1 mutants.
      Title: gurke and pasticcino3 mutants affected in embryo development are impaired in acetyl-CoA carboxylase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198214.2
    NM_103313.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acetyl-CoA carboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables biotin carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cold acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within primary shoot apical meristem specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokinin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    acetyl-CoA carboxylase 1
    NP_001185143.1
    • acetyl-CoA carboxylase 1 (ACC1); CONTAINS InterPro DOMAIN/s: Acetyl-coenzyme A carboxyltransferase, N-terminal (InterPro:IPR011762), Carboxyl transferase (InterPro:IPR000022), Biotin/lipoyl attachment (InterPro:IPR000089), Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), PreATP-grasp-like fold (InterPro:IPR016185), ATP-grasp fold (InterPro:IPR011761), Biotin carboxylase, C-terminal (InterPro:IPR005482), Single hybrid motif (InterPro:IPR011053), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), Acetyl-CoA carboxylase, central region (InterPro:IPR013537), Biotin carboxylation domain (InterPro:IPR011764), Biotin-binding site (InterPro:IPR001882), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Acetyl-coenzyme A carboxyltransferase, C-terminal (InterPro:IPR011763), Pre-ATP-grasp fold (InterPro:IPR013817), Rudiment single hybrid motif (InterPro:IPR011054); BEST Arabidopsis thaliana protein match is: acetyl-CoA carboxylase 2 (TAIR:AT1G36180.1).
    NP_174849.2
    • acetyl-CoA carboxylase 1 (ACC1); FUNCTIONS IN: acetyl-CoA carboxylase activity; INVOLVED IN: in 7 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Acetyl-coenzyme A carboxyltransferase, N-terminal (InterPro:IPR011762), Carboxyl transferase (InterPro:IPR000022), Biotin/lipoyl attachment (InterPro:IPR000089), Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), PreATP-grasp-like fold (InterPro:IPR016185), ATP-grasp fold (InterPro:IPR011761), Biotin carboxylase, C-terminal (InterPro:IPR005482), Single hybrid motif (InterPro:IPR011053), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), Acetyl-CoA carboxylase, central region (InterPro:IPR013537), Biotin carboxylation domain (InterPro:IPR011764), Biotin-binding site (InterPro:IPR001882), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Acetyl-coenzyme A carboxyltransferase, C-terminal (InterPro:IPR011763), Pre-ATP-grasp fold (InterPro:IPR013817), Rudiment single hybrid motif (InterPro:IPR011054); BEST Arabidopsis thaliana protein match is: acetyl-CoA carboxylase 2 (TAIR:AT1G36180.1); Has 35904 Blast hits to 31362 proteins in 3745 species: Archae - 652; Bacteria - 22267; Metazoa - 1934; Fungi - 1046; Plants - 1042; Viruses - 0; Other Eukaryotes - 8963 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      13533168..13544015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198214.2 → NP_001185143.1  acetyl-CoA carboxylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185143.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNF3, Q38970, Q38971, Q9C8G1, Q9SKV1
      UniProtKB/TrEMBL
      A0A178W1F6, A0A5S9WJ11
      Conserved Domains (8) summary
      cd06850
      Location:679 → 741
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:40 → 545
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:601 → 741
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:37 → 156
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1587 → 2139
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:432 → 539
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:744 → 1485
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:161 → 385
      ATP-grasp_4; ATP-grasp domain

    2. NM_103313.4 → NP_174849.2  acetyl-CoA carboxylase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174849.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WNF3, Q38970, Q38971, Q9C8G1, Q9SKV1
      UniProtKB/TrEMBL
      A0A178W1F6, A0A5S9WJ11
      Conserved Domains (8) summary
      cd06850
      Location:679 → 741
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:40 → 545
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      COG0511
      Location:601 → 741
      AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
      pfam00289
      Location:37 → 156
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1587 → 2139
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:432 → 539
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:744 → 1485
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:161 → 385
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38970.1

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