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    GAPC2 glyceraldehyde-3-phosphate dehydrogenase C2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837904, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GAPC2
    Official Full Name
    glyceraldehyde-3-phosphate dehydrogenase C2
    Primary source
    TAIR:AT1G13440
    Locus tag
    AT1G13440
    See related
    Araport:AT1G13440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GAPC-2; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE C-2; glyceraldehyde-3-phosphate dehydrogenase C2; T6J4.17; T6J4_17
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    Genomic context

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    See GAPC2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (4608077..4610878, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene sulfotransferase 4B Neighboring gene sulfotransferase 4C Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Homeodomain-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytosolic GAPDH as a redox-dependent regulator of energy metabolism. Schneider M, et al. BMC Plant Biol, 2018 Sep 6. PMID 30189844, Free PMC Article
    2. AtCAP2 is crucial for lytic vacuole biogenesis during germination by positively regulating vacuolar protein trafficking. Kwon Y, et al. Proc Natl Acad Sci U S A, 2018 Feb 13. PMID 29378957, Free PMC Article
    3. Regulation of plant cytosolic glyceraldehyde 3-phosphate dehydrogenase isoforms by thiol modifications. Holtgrefe S, et al. Physiol Plant, 2008 Jun. PMID 18298409
    4. Cytosolic phosphorylating glyceraldehyde-3-phosphate dehydrogenases affect Arabidopsis cellular metabolism and promote seed oil accumulation. Guo L, et al. Plant Cell, 2014 Jul. PMID 24989043, Free PMC Article
    5. Nuclear moonlighting of cytosolic glyceraldehyde-3-phosphate dehydrogenase regulates Arabidopsis response to heat stress. Kim SC, et al. Nat Commun, 2020 Jul 10. PMID 32651385, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the redox-dependent localization of GapC1 and GapC2 in the different cellular subcompartments and their interactions with VDAC3 and Trx-h3
      Title: Cytosolic GAPDH as a redox-dependent regulator of energy metabolism.
    2. GAPC levels play important roles in the overall cellular production of reductants, energy, and carbohydrate metabolites and that GAPC levels are directly correlated with seed oil accumulation.
      Title: Cytosolic phosphorylating glyceraldehyde-3-phosphate dehydrogenases affect Arabidopsis cellular metabolism and promote seed oil accumulation.
    3. The addition of GSSG, and much more efficiently of S-nitrosoglutathione, was shown to inactivate the enzymes GapC1 and GapC2 from Arabidopsis thaliana, spinach, yeast and rabbit muscle. [GapC2]
      Title: Regulation of plant cytosolic glyceraldehyde 3-phosphate dehydrogenase isoforms by thiol modifications.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084061.1
    NM_101214.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding HDA PubMed 
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables salicylic acid binding HDA PubMed 
    enables zinc ion binding HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within gluconeogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycolytic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    glyceraldehyde-3-phosphate dehydrogenase C2
    NP_001077530.1
    • glyceraldehyde-3-phosphate dehydrogenase C2 (GAPC2); FUNCTIONS IN: copper ion binding, glyceraldehyde-3-phosphate dehydrogenase activity, zinc ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, gluconeogenesis, defense response to bacterium, glycolysis; LOCATED IN: cytosol, mitochondrion, chloroplast, plasma membrane, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain (InterPro:IPR020829), Glyceraldehyde 3-phosphate dehydrogenase subfamily (InterPro:IPR000173), Glyceraldehyde 3-phosphate dehydrogenase family (InterPro:IPR020831), Glyceraldehyde-3-phosphate dehydrogenase, type I (InterPro:IPR006424), Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain (InterPro:IPR020828); BEST Arabidopsis thaliana protein match is: glyceraldehyde-3-phosphate dehydrogenase C subunit 1 (TAIR:AT3G04120.1); Has 25183 Blast hits to 25173 proteins in 6340 species: Archae - 41; Bacteria - 10793; Metazoa - 2402; Fungi - 2843; Plants - 3866; Viruses - 0; Other Eukaryotes - 5238 (source: NCBI BLink).
    NP_172801.1
    • glyceraldehyde-3-phosphate dehydrogenase C2 (GAPC2); FUNCTIONS IN: copper ion binding, glyceraldehyde-3-phosphate dehydrogenase activity, zinc ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, gluconeogenesis, defense response to bacterium, glycolysis; LOCATED IN: in 8 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Glyceraldehyde 3-phosphate dehydrogenase subfamily (InterPro:IPR000173), Glyceraldehyde 3-phosphate dehydrogenase family (InterPro:IPR020831), Glyceraldehyde-3-phosphate dehydrogenase, type I (InterPro:IPR006424), Glyceraldehyde 3-phosphate dehydrogenase, active site (InterPro:IPR020830), Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain (InterPro:IPR020829), Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain, subgroup (InterPro:IPR020832), Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain (InterPro:IPR020828); BEST Arabidopsis thaliana protein match is: glyceraldehyde-3-phosphate dehydrogenase C subunit 1 (TAIR:AT3G04120.1); Has 25382 Blast hits to 25370 proteins in 6374 species: Archae - 87; Bacteria - 10988; Metazoa - 2357; Fungi - 2864; Plants - 3864; Viruses - 0; Other Eukaryotes - 5222 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4608077..4610878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101214.4 → NP_172801.1  glyceraldehyde-3-phosphate dehydrogenase C2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172801.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DGZ4, Q9FX54
      UniProtKB/TrEMBL
      A0A178W4Q5, A0A5S9U6P9, A0A5S9X911
      Conserved Domains (1) summary
      PLN02358
      Location:1 → 338
      PLN02358; glyceraldehyde-3-phosphate dehydrogenase

    2. NM_001084061.1 → NP_001077530.1  glyceraldehyde-3-phosphate dehydrogenase C2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077530.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X911, F4HQT1
      Conserved Domains (3) summary
      PLN02358
      Location:1 → 310
      PLN02358; glyceraldehyde-3-phosphate dehydrogenase
      pfam00044
      Location:6 → 144
      Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
      pfam02800
      Location:143 → 290
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FX54.1

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