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    MYB5 myb domain protein 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820556, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MYB5
    Official Full Name
    myb domain protein 5
    Primary source
    TAIR:AT3G13540
    Locus tag
    AT3G13540
    See related
    Araport:AT3G13540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABC transporter of the mitochondrion 2; ATM2; ATMYB5; myb domain protein 5
    Summary
    Encodes a member of the MYB family of transcriptional regulators. MYB5 act as a negative regulator of trichome branching and play a role in the correct formation of the seed coat and possibly the formation the underlying endosperm layers. Loss of function mutations have defects in seed coat mucilage and columella cells as well as trichome defects (smaller and reduced number of branches).
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    Genomic context

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    See MYB5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (4419960..4421751)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitogen-activated protein kinase kinase kinase 7 Neighboring gene ncRNA Neighboring gene Ubiquitin-conjugating enzyme family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MYB-bHLH-TTG1 in a Multi-tiered Pathway Regulates Arabidopsis Seed Coat Mucilage Biosynthesis Genes Including PECTIN METHYLESTERASE INHIBITOR14 Required for Homogalacturonan Demethylesterification. Allen PJ, et al. Plant Cell Physiol, 2023 Aug 17. PMID 37354456, Free PMC Article
    2. The Arabidopsis MYB5 transcription factor regulates mucilage synthesis, seed coat development, and trichome morphogenesis. Li SF, et al. Plant Cell, 2009 Jan. PMID 19136646, Free PMC Article
    3. A novel myb-related gene from Arabidopsis thaliana. Li SF, et al. FEBS Lett, 1996 Jan 29. PMID 8635574
    4. The Seed Development Factors TT2 and MYB5 Regulate Heat Stress Response in Arabidopsis. Jacob P, et al. Genes (Basel), 2021 May 15. PMID 34063415, Free PMC Article
    5. TTG1 complex MYBs, MYB5 and TT2, control outer seed coat differentiation. Gonzalez A, et al. Dev Biol, 2009 Jan 15. PMID 18992236

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Seed Development Factors TT2 and MYB5 Regulate Heat Stress Response in Arabidopsis.
      Title: The Seed Development Factors TT2 and MYB5 Regulate Heat Stress Response in Arabidopsis.
    2. This publication identifies AtMYB5 and TT2, as partially redundant in regulating the outer seed coat developmental process with MYB5 having the major role. MYB5 and TT2 are shown to be expressed in this outer seed coat domain. [MYB5]
      Title: TTG1 complex MYBs, MYB5 and TT2, control outer seed coat differentiation.
    3. MYB5 gene is expressed in trichomes and seeds, and regulates trichome extension and branching.
      Title: The Arabidopsis MYB5 transcription factor regulates mucilage synthesis, seed coat development, and trichome morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112200.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mucilage biosynthetic process involved in seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within trichome differentiation NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within trichome morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    myb domain protein 5
    NP_187963.1
    • myb domain protein 5 (MYB5); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 17 (TAIR:AT3G61250.1); Has 8972 Blast hits to 8275 proteins in 512 species: Archae - 0; Bacteria - 0; Metazoa - 834; Fungi - 461; Plants - 5987; Viruses - 3; Other Eukaryotes - 1687 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4419960..4421751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112200.3 → NP_187963.1  myb domain protein 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187963.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38850
      UniProtKB/TrEMBL
      A0A178VAR4, A0A5S9XC04
      Conserved Domains (1) summary
      PLN03212
      Location:1 → 249
      PLN03212; Transcription repressor MYB5; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38850.1

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