KU70 ATP-dependent DNA helicase 2 subunit Ku70-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: KU70
Official Full Name: ATP-dependent DNA helicase 2 subunit Ku70-like protein
Primary source: TAIR:AT1G16970
Locus tag: AT1G16970
See related: Araport:AT1G16970
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA KU70 HOMOLOG; ATKU70; F6I1.2; F6I1_2; KU70 homolog; KU70-LIKE PROTEIN
Summary: Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity.
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Genomic context

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See KU70 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 18

Sequence:: Chromosome: 1; NC_003070.9 (5800767..5805811, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KU70 and CAF-1 in Arabidopsis: Divergent roles in rDNA stability and telomere homeostasis.
Title: KU70 and CAF-1 in Arabidopsis: Divergent roles in rDNA stability and telomere homeostasis.
Ku70 and Ku80 expression in 3-week-old young seedlings were down-regulated by heat stress in a time-dependent manner, as examined using real-time quantitative PCR, GUS reporter systems, and western blotting analysis.
Title: Regulation of Arabidopsis thaliana Ku genes at different developmental stages under heat stress.
Ku70/80 specifically inhibits circle formation at telomeres, but not at centromeric and ribosomal DNA repeats.
Title: Ku suppresses formation of telomeric circles and alternative telomere lengthening in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101558.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables telomeric DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within telomere maintenance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within telomere maintenance	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of Ku70:Ku80 complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: ATP-dependent DNA helicase 2 subunit Ku70-like protein

NP_564012.1

KU70 homolog (KU70); FUNCTIONS IN: double-stranded DNA binding, protein binding; INVOLVED IN: DNA repair, response to heat, telomere maintenance; LOCATED IN: nucleus, DNA-dependent protein kinase-DNA ligase 4 complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ku70/Ku80, N-terminal alpha/beta (InterPro:IPR005161), DNA-binding SAP (InterPro:IPR003034), DNA helicase, ATP-dependent, Ku type (InterPro:IPR006164), Spen Paralogue and Orthologue SPOC, C-terminal-like (InterPro:IPR016194), Ku70/Ku80 C-terminal arm (InterPro:IPR005160), DNA helicase, ATP-dependent, Ku70 subunit (InterPro:IPR006165); Has 475 Blast hits to 466 proteins in 181 species: Archae - 0; Bacteria - 6; Metazoa - 182; Fungi - 177; Plants - 52; Viruses - 0; Other Eukaryotes - 58 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

5800767..5805811 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101558.4 → NP_564012.1 ATP-dependent DNA helicase 2 subunit Ku70-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564012.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FQ08, Q9FZ56

UniProtKB/TrEMBL

A0A178WAS1, A0A5S9UT82

Conserved Domains (2) summary

cd00788
Location:265 → 544

KU70; Ku-core domain, Ku70 subfamily; Ku70 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...

TIGR00578
Location:24 → 619

ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)