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    NAD(P)-linked oxidoreductase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829509, updated on 18-Sep-2024

    Summary

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    Official Full Name
    NAD(P)-linked oxidoreductase superfamily protein
    Primary source
    TAIR:AT4G33670
    Locus tag
    AT4G33670
    See related
    Araport:AT4G33670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T16L1.160; T16L1_160
    Summary
    Encodes a L-galactose dehydrogenase, involved in ascorbate biosynthesis
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (16169523..16171631, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene cysteine-rich TM module stress tolerance protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Neighboring gene G patch domain protein Neighboring gene CBS domain protein (DUF21)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional assignment of Glu386 and Arg388 in the active site of L-galactono-gamma-lactone dehydrogenase. Leferink NG, et al. FEBS Lett, 2009 Oct 6. PMID 19737562
    2. Identification of a gatekeeper residue that prevents dehydrogenases from acting as oxidases. Leferink NG, et al. J Biol Chem, 2009 Feb 13. PMID 19088070
    3. Antisense suppression of l-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated l-galactose synthesis. Gatzek S, et al. Plant J, 2002 Jun. PMID 12047629
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The E386D variant has lost its specificity for L-galactono-1,4-lactone and shows the highest catalytic efficiency with L-gulono-1,4-lactone.
      Title: Functional assignment of Glu386 and Arg388 in the active site of L-galactono-gamma-lactone dehydrogenase.
    2. a single Ala to Gly substitution in l-galactono-gamma-lactone dehydrogenase (GALDH) turns the enzyme into a catalytically competent oxidase
      Title: Identification of a gatekeeper residue that prevents dehydrogenases from acting as oxidases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_119525.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-galactose dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-ascorbic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    NAD(P)-linked oxidoreductase superfamily protein
    NP_195093.1
    • NAD(P)-linked oxidoreductase superfamily protein; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT1G60750.1); Has 28637 Blast hits to 28630 proteins in 2499 species: Archae - 653; Bacteria - 20546; Metazoa - 1049; Fungi - 1796; Plants - 827; Viruses - 0; Other Eukaryotes - 3766 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16169523..16171631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119525.6 → NP_195093.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195093.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D9IZZ0, O81884
      UniProtKB/TrEMBL
      A0A178USL2, A0A5S9XZ76, A0A654FV60
      Conserved Domains (1) summary
      PLN02587
      Location:6 → 319
      PLN02587; L-galactose dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81884.1

    Gene LinkOut

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