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    CPK5 calmodulin-domain protein kinase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829685, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPK5
    Official Full Name
    calmodulin-domain protein kinase 5
    Primary source
    TAIR:AT4G35310
    Locus tag
    AT4G35310
    See related
    Araport:AT4G35310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCPK5; calmodulin-domain protein kinase 5; CALMODULIN-DOMAIN PROTEIN KINASE 5; F23E12.130; F23E12_130
    Summary
    calmodulin-domain protein kinase CDPK isoform 5 (CPK5)
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    Genomic context

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    See CPK5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (16801605..16805005)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene homoserine kinase, putative / HSK Neighboring gene tonoplast monosaccharide transporter2 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Nucleotide-sugar transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calcium-dependent protein kinase 5 links calcium signaling with N-hydroxy-l-pipecolic acid- and SARD1-dependent immune memory in systemic acquired resistance. Guerra T, et al. New Phytol, 2020 Jan. PMID 31469917
    2. CALCIUM-DEPENDENT PROTEIN KINASE5 Associates with the Truncated NLR Protein TIR-NBS2 to Contribute to exo70B1-Mediated Immunity. Liu N, et al. Plant Cell, 2017 Apr. PMID 28351987, Free PMC Article
    3. Calcium-dependent protein kinase/NADPH oxidase activation circuit is required for rapid defense signal propagation. Dubiella U, et al. Proc Natl Acad Sci U S A, 2013 May 21. PMID 23650383, Free PMC Article
    4. Calcium-dependent ABA signaling functions in stomatal immunity by regulating rapid SA responses in guard cells. Ou X, et al. J Plant Physiol, 2022 Jan. PMID 34894596
    5. The myristoylated amino-terminus of an Arabidopsis calcium-dependent protein kinase mediates plasma membrane localization. Lu SX, et al. Plant Mol Biol, 2013 Jun. PMID 23609608, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calcium-dependent ABA signaling functions in stomatal immunity by regulating rapid SA responses in guard cells.
      Title: Calcium-dependent ABA signaling functions in stomatal immunity by regulating rapid SA responses in guard cells.
    2. Calcium-dependent protein kinase 5 links calcium signaling with N-hydroxy-l-pipecolic acid- and SARD1-dependent immune memory in systemic acquired resistance.
      Title: Calcium-dependent protein kinase 5 links calcium signaling with N-hydroxy-l-pipecolic acid- and SARD1-dependent immune memory in systemic acquired resistance.
    3. The work uncovers a direct functional link between an atypical immune receptor and a crucial component of early immune signaling: increased immunity in exo70B1 depends on TN2 and CPK5 and, in a positive feedback loop, TN2 keeps CPK5 enzymatically active beyond the initiating stimulus.
      Title: CALCIUM-DEPENDENT PROTEIN KINASE5 Associates with the Truncated NLR Protein TIR-NBS2 to Contribute to exo70B1-Mediated Immunity.
    4. Results indicate that AtCPK5 is myristoylated at its amino terminus and that myristoylation is required for membrane binding.
      Title: The myristoylated amino-terminus of an Arabidopsis calcium-dependent protein kinase mediates plasma membrane localization.
    5. a model of ROS-mediated cell-to-cell communication, where a self-propagating mutual activation circuit consisting of the protein kinase, CPK5, and the NADPH oxidase RBOHD facilitates rapid signal propagation
      Title: Calcium-dependent protein kinase/NADPH oxidase activation circuit is required for rapid defense signal propagation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001342345.1
    NM_119697.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-domain protein kinase 5
    NP_195257.1
    • calmodulin-domain protein kinase 5 (CPK5); FUNCTIONS IN: in 6 functions; INVOLVED IN: protein amino acid phosphorylation, N-terminal protein myristoylation; LOCATED IN: cytosol, plasma membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: Calcium-dependent protein kinase family protein (TAIR:AT2G17290.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16801605..16805005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119697.4 → NP_195257.1  calmodulin-domain protein kinase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195257.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38871
      UniProtKB/TrEMBL
      A0A178V3J8, A0A5S9XYT8
      Conserved Domains (2) summary
      PTZ00184
      Location:391 → 533
      PTZ00184; calmodulin; Provisional
      cd05117
      Location:97 → 354
      STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases

    2. NM_001342345.1 → NP_001329080.1  calmodulin-domain protein kinase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38871
      UniProtKB/TrEMBL
      A0A178V3J8, A0A5S9XYT8
      Conserved Domains (2) summary
      PTZ00184
      Location:391 → 533
      PTZ00184; calmodulin; Provisional
      cd05117
      Location:97 → 354
      STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38871.1

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