SRFR1 Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: SRFR1
Official Full Name: Tetratricopeptide repeat (TPR)-like superfamily protein
Primary source: TAIR:AT4G37460
Locus tag: AT4G37460
See related: Araport:AT4G37460
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F6G17.110; F6G17_110; SUPPRESSOR OF RPS4-RLD 1
Summary: Encodes a tetratricopeptide repeat domain containing protein that shows sequence similarity to those of transcriptional repressors in other organisms. Involved in mediating effector-triggered immunity.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See SRFR1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 23

Sequence:: Chromosome: 4; NC_003075.7 (17608378..17615946, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conserved Opposite Functions in Plant Resistance to Biotrophic and Necrotrophic Pathogens of the Immune Regulator SRFR1.
Title: Conserved Opposite Functions in Plant Resistance to Biotrophic and Necrotrophic Pathogens of the Immune Regulator SRFR1.
This finding suggests a novel form of resistance in Arabidopsis to the biotrophic pathogen H. schachtii or a root-specific regulation of the salicylic acid pathway by EDS1, and places SRFR1 at an intersection between multiple defence pathways.
Title: The Arabidopsis immune regulator SRFR1 dampens defences against herbivory by Spodoptera exigua and parasitism by Heterodera schachtii.
SRFR1 has a role in regulating effector-triggered immunity via transcriptional control.
Title: The Arabidopsis immune adaptor SRFR1 interacts with TCP transcription factors that redundantly contribute to effector-triggered immunity.
study shows EDS1 forms complexes with the TIR-NB-LRR resistance proteins RPS4 and RPS6 and the negative immune regulator SRFR1 at a cytoplasmic membrane
Title: Pathogen effectors target Arabidopsis EDS1 and alter its interactions with immune regulators.
Mutations in SRFR1 activates SNC1 and contributes to resistance to the bacterial effector AvrRps4.
Title: The Arabidopsis resistance-like gene SNC1 is activated by mutations in SRFR1 and contributes to resistance to the bacterial effector AvrRps4.
Mutations in SRFR1 also enhanced HopA1-triggered immunity in rps6 mutants.
Title: Resistance to the Pseudomonas syringae effector HopA1 is governed by the TIR-NBS-LRR protein RPS6 and is enhanced by mutations in SRFR1.
SRFR1 is a single-copy gene encoding a conserved tetratricopeptide repeat protein, and is a negative regulator of effector-triggered immunity to avrRps4.
Title: SRFR1, a suppressor of effector-triggered immunity, encodes a conserved tetratricopeptide repeat protein with similarity to transcriptional repressors.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_001342443.1

Supported by ESTs:

NM_119910.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular adaptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of defense response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Tetratricopeptide repeat (TPR)-like superfamily protein

NP_195462.3

SUPPRESSOR OF RPS4-RLD 1 (SRFR1); FUNCTIONS IN: protein complex scaffold; INVOLVED IN: defense response to bacterium, incompatible interaction, defense response to bacterium, negative regulation of transcription, negative regulation of defense response; LOCATED IN: nucleus, perinuclear region of cytoplasm, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT3G04240.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

17608378..17615946 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119910.4 → NP_195462.3 Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195462.3

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JS25, Q8GYX1, Q9SZU6

UniProtKB/TrEMBL

A0A178V335, A0A5S9Y1P8

Conserved Domains (3) summary

COG0457
Location:276 → 531

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

TIGR00990
Location:19 → 492

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:297 → 325

TPR; TPR repeat [structural motif]
NM_001342443.1 → NP_001329700.1 Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B8I2, A0A5S9Y1P8

Conserved Domains (3) summary

TIGR00990
Location:19 → 492

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

TIGR02917
Location:303 → 495

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:297 → 325

TPR; TPR repeat [structural motif]