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    CRK4 cysteine-rich RLK (RECEPTOR-like protein kinase) 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823729, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRK4
    Official Full Name
    cysteine-rich RLK (RECEPTOR-like protein kinase) 4
    Primary source
    TAIR:AT3G45860
    Locus tag
    AT3G45860
    See related
    Araport:AT3G45860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cysteine-rich RLK (RECEPTOR-like protein kinase) 4
    Summary
    Encodes a cysteine-rich receptor-like protein kinase. Involved in programmed cell death and defense response to pathogen.
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    Genomic context

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    See CRK4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (16863088..16866261, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene nodulin MtN21 /EamA-like transporter family protein Neighboring gene ncRNA Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene root UVB sensitive-like protein (Protein of unknown function, DUF647)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation. de Oliveira MV, et al. Nat Plants, 2016 Jan 25. PMID 27250875, Free PMC Article
    2. Identification of genes encoding receptor-like protein kinases as possible targets of pathogen- and salicylic acid-induced WRKY DNA-binding proteins in Arabidopsis. Du L, et al. Plant J, 2000 Dec. PMID 11135117
    3. Enhanced Arabidopsis pattern-triggered immunity by overexpression of cysteine-rich receptor-like kinases. Yeh YH, et al. Front Plant Sci, 2015. PMID 26029224, Free PMC Article
    4. Activation of hypersensitive cell death by pathogen-induced receptor-like protein kinases from Arabidopsis. Chen K, et al. Plant Mol Biol, 2004 Sep. PMID 15604743
    5. Marker and readout genes for defense priming in Pseudomonas cannabina pv. alisalensis interaction aid understanding systemic immunity in Arabidopsis. Sistenich AJ, et al. Sci Rep, 2024 Feb 12. PMID 38347062, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114455.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within priming of cellular response to stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine-rich RLK (RECEPTOR-like protein kinase) 4
    NP_190172.1
    • cysteine-rich RLK (RECEPTOR-like protein kinase) 4 (CRK4); FUNCTIONS IN: kinase activity; INVOLVED IN: defense response to bacterium, defense response, programmed cell death, response to salicylic acid stimulus; LOCATED IN: endomembrane system; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Protein of unknown function DUF26 (InterPro:IPR002902), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cysteine-rich RLK (RECEPTOR-like protein kinase) 19 (TAIR:AT4G23270.1); Has 119379 Blast hits to 118105 proteins in 4551 species: Archae - 90; Bacteria - 13618; Metazoa - 44322; Fungi - 10003; Plants - 33611; Viruses - 380; Other Eukaryotes - 17355 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      16863088..16866261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114455.2 → NP_190172.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190172.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LZU4
      UniProtKB/TrEMBL
      A0A5S9XJU2, A0A654FF15
      Conserved Domains (2) summary
      cd14066
      Location:357 → 625
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam01657
      Location:36 → 131
      Stress-antifung; Salt stress response/antifungal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LZU4.1

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