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    CPSRP54 chloroplast signal recognition particle 54 kDa subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830273, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPSRP54
    Official Full Name
    chloroplast signal recognition particle 54 kDa subunit
    Primary source
    TAIR:AT5G03940
    Locus tag
    AT5G03940
    See related
    Araport:AT5G03940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    54 CHLOROPLAST PROTEIN; 54CP; chloroplast signal recognition particle 54 kDa subunit; F8F6.150; F8F6_150; FFC; FIFTY-FOUR CHLOROPLAST HOMOLOGUE; SIGNAL RECOGNITION PARTICLE 54 KDA SUBUNIT; SIGNAL RECOGNITION PARTICLE 54 KDA SUBUNIT CHLOROPLAST PROTEIN; SRP54CP
    Summary
    mutant has Yellow first leaves; Chloroplast Signal Recognition Particle Subunit
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    Genomic context

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    See CPSRP54 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (1060106..1063425, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Iron-sulfur cluster biosynthesis family protein Neighboring gene ABC2 homolog 12 Neighboring gene F-box protein Neighboring gene F-box protein Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis cpSRP54 regulates carotenoid accumulation in Arabidopsis and Brassica napus. Yu B, et al. J Exp Bot, 2012 Sep. PMID 22791829, Free PMC Article
    2. Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates. Gao F, et al. J Biol Chem, 2015 Jun 19. PMID 25918165, Free PMC Article
    3. Chloroplast FtsY, chloroplast signal recognition particle, and GTP are required to reconstitute the soluble phase of light-harvesting chlorophyll protein transport into thylakoid membranes. Tu CJ, et al. J Biol Chem, 1999 Sep 17. PMID 10480939
    4. Regulation of the GTPase cycle in post-translational signal recognition particle-based protein targeting involves cpSRP43. Goforth RL, et al. J Biol Chem, 2004 Oct 8. PMID 15292240
    5. Assembly of chloroplast signal recognition particle involves structural rearrangement in cpSRP43. Kathir KM, et al. J Mol Biol, 2008 Aug 1. PMID 18586266, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results support the conclusion that substrate binding to the chloroplast SRP is modulated by protein structural dynamics in which a major role of cpSRP54 is to improve substrate binding efficiency to the cpSRP.
      Title: Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates.
    2. cbd is a recessive mutant in the gene cpSRP54 encoding the 54 kDa subunit of the chloroplast signal recognition particle. Relative to wild type, expression increased in carotenoid and abscisic acid catabolic genes.
      Title: Arabidopsis cpSRP54 regulates carotenoid accumulation in Arabidopsis and Brassica napus.
    3. The authors report the crystal structure of the chloroplast signal recognition particle (cpSRP) core from Arabidopsis thaliana, with the cpSRP54 tail comprising an arginine-rich motif bound to the second chromodomain of cpSRP43.
      Title: Chromodomains read the arginine code of post-translational targeting.
    4. cpSRP54 deletion led to a change in light-harvesting complex composition, an increase of PsbS, a decreased photosystem I/II ratio, and, in young leaves, to up-regulation of thylakoid proteases and stromal chaperones, including ClpC
      Title: Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_120476.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signal sequence binding IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein import into chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane HDA PubMed 
    part_of signal recognition particle, chloroplast targeting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chloroplast signal recognition particle 54 kDa subunit
    NP_196014.1
    • chloroplast signal recognition particle 54 kDa subunit (CPSRP54); FUNCTIONS IN: 7S RNA binding, protein binding, mRNA binding, GTP binding, signal sequence binding; INVOLVED IN: protein import into chloroplast thylakoid membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; LOCATED IN: chloroplast stroma, chloroplast, signal recognition particle, chloroplast targeting, signal recognition particle, endoplasmic reticulum targeting; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), Signal recognition particle, SRP (InterPro:IPR004780), Signal recognition particle, SRP54 subunit, helical bundle (InterPro:IPR013822), Signal recognition particle, SRP54 subunit, M-domain (InterPro:IPR004125), Signal recognition particle, SRP54 subunit, GTPase (InterPro:IPR000897); BEST Arabidopsis thaliana protein match is: Signal recognition particle, SRP54 subunit protein (TAIR:AT1G48900.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1060106..1063425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120476.5 → NP_196014.1  chloroplast signal recognition particle 54 kDa subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196014.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82570, P37107
      UniProtKB/TrEMBL
      A0A178UD49, A0A5S9Y3D9, A0A7G2F4W1
      Conserved Domains (1) summary
      PRK10867
      Location:77 → 507
      PRK10867; signal recognition particle protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37107.1

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