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    AGL15 AGAMOUS-like 15 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831224, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGL15
    Official Full Name
    AGAMOUS-like 15
    Primary source
    TAIR:AT5G13790
    Locus tag
    AT5G13790
    See related
    Araport:AT5G13790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS-like 15; MADS-BOX PROTEIN AGL15; MXE10.8; MXE10_8
    Summary
    AGL15 (AGAMOUS-Like 15) is a member of the MADS domain family of regulatory factors. Although AGL15 is preferentially expressed during embryogenesis, AGL15 is also expressed in leaf primordia, shoot apical meristems and young floral buds, suggesting that AGL15 may play a role during post-germinative development. Transgenic plants that ectopically express AGL15 show delays in the transition to flowering, perianth abscission and senescence and fruit and seed maturation. Role in embryogenesis and gibberellic acid catabolism. Targets B3 domain transcription factors that are key regulators of embryogenesis.
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    Genomic context

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    See AGL15 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (4448862..4450958, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Plasma-membrane choline transporter family protein Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein Neighboring gene pheophytinase Neighboring gene Glutaredoxin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MADS domain protein AGL15 localizes to the nucleus during early stages of seed development. Perry SE, et al. Plant Cell, 1996 Nov. PMID 8953767, Free PMC Article
    2. The MADS-domain protein AGAMOUS-like 15 accumulates in embryonic tissues with diverse origins. Perry SE, et al. Plant Physiol, 1999 May. PMID 10318690, Free PMC Article
    3. The embryo MADS domain factor AGL15 acts postembryonically. Inhibition of perianth senescence and abscission via constitutive expression. Fernandez DE, et al. Plant Cell, 2000 Feb. PMID 10662856, Free PMC Article
    4. Effect of regulated overexpression of the MADS domain factor AGL15 on flower senescence and fruit maturation. Fang SC, et al. Plant Physiol, 2002 Sep. PMID 12226488, Free PMC Article
    5. Binding site selection for the plant MADS domain protein AGL15: an in vitro and in vivo study. Tang W, et al. J Biol Chem, 2003 Jul 25. PMID 12743119

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brassinosteroids repress the seed maturation program during the seed-to-seedling transition.
      Title: Brassinosteroids repress the seed maturation program during the seed-to-seedling transition.
    2. PRX17, under the control of AGL15, contributes to developmental programs by playing an essential role in regulating age-dependent lignified tissue formation, including changes in cell wall properties.
      Title: The class III peroxidase PRX17 is a direct target of the MADS-box transcription factor AGAMOUS-LIKE15 (AGL15) and participates in lignified tissue formation.
    3. AGL15 negatively regulates auxin signaling in both Arabidopsis and soybean at many levels of the pathway.
      Title: Gene Regulation by the AGL15 Transcription Factor Reveals Hormone Interactions in Somatic Embryogenesis.
    4. AGL15 and AGL18 may form a complex along with other proteins, and bind to the CArG motifs of the promoters of MIR156 to activate the MIR156 expression.
      Title: Expression of the floral repressor miRNA156 is positively regulated by the AGAMOUS-like proteins AGL15 and AGL18.
    5. confirmation that At5g61590 is a directly expressed target of AGL15 and that At5g61590 is essential for AGL15's promotion of somatic embryogenesis.
      Title: AGAMOUS-Like15 promotes somatic embryogenesis in Arabidopsis and soybean in part by the control of ethylene biosynthesis and response.
    6. Several key regulators of embryogenesis were directly expressed in response to AGL15.
      Title: Global identification of targets of the Arabidopsis MADS domain protein AGAMOUS-Like15.
    7. LFY and AGL15 are involved in the regulation of AtMYB17 in early inflorescence development and seed germination.
      Title: Characterization of Arabidopsis MYB transcription factor gene AtMYB17 and its possible regulation by LEAFY and AGL15.
    8. Flowering time is determined by the additive effect of multiple MADS domain floral repressors, with important contributions from AGL15 and AGL18.
      Title: The MADS domain factors AGL15 and AGL18 act redundantly as repressors of the floral transition in Arabidopsis.
    9. Regions important for the level of expression, including a region involved in expression in response to auxin, were identified. Additionally, AGL15 expression was found to respond to AGL15 accumulation amounts and to altered forms of AGL15.
      Title: Control of expression and autoregulation of AGL15, a member of the MADS-box family.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121382.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to auxin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within floral organ abscission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within floral organ abscission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fruit abscission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fruit dehiscence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gibberellin catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of floral organ abscission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of seed maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of short-day photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in somatic embryogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AGAMOUS-like 15
    NP_196883.1
    • AGAMOUS-like 15 (AGL15); CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: AGAMOUS-like 18 (TAIR:AT3G57390.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4448862..4450958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343293.1 → NP_001330207.1  AGAMOUS-like 15 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UBU5, A0A1P8BA33, A0A384LKZ8
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:75 → 168
      K-box; K-box region

    2. NM_121382.3 → NP_196883.1  AGAMOUS-like 15 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38839, Q38847
      UniProtKB/TrEMBL
      A0A178U9X9
      Conserved Domains (2) summary
      cd00265
      Location:2 → 78
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:75 → 163
      K-box; K-box region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38847.1

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