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    ABO1 IKI3 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831213, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABO1
    Official Full Name
    IKI3 family protein
    Primary source
    TAIR:AT5G13680
    Locus tag
    AT5G13680
    See related
    Araport:AT5G13680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABA-OVERLY SENSITIVE 1; AtELP1; ELO2; ELONGATA 2; MSH12.15; MSH12_15
    Summary
    A subunit of Elongator, a histone acetyl transferase complex, consisting of six subunits (ELP1#AeiELP6), that copurifies with the elongating RNAPII in yeast and humans. Three Arabidopsis thaliana genes, encoding homologs of the yeast Elongator subunits ELP1, ELP3 (histone acetyl transferase), and ELP4 are responsible for the narrow leaf phenotype in elongata mutants and for reduced root growth that results from a decreased cell division rate. Mutants have no ncm5U (5-carbamoylmethyluridine).
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    Genomic context

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    See ABO1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (4410314..4415622, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene N-lysine methyltransferase Neighboring gene nodulin MtN21 /EamA-like transporter family protein Neighboring gene alpha-N-acetylglucosaminidase family / NAGLU family Neighboring gene polyamine oxidase 1 Neighboring gene sterol methyltransferase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in ABO1/ELO2, a subunit of holo-Elongator, increase abscisic acid sensitivity and drought tolerance in Arabidopsis thaliana. Chen Z, et al. Mol Cell Biol, 2006 Sep. PMID 16943431, Free PMC Article
    2. The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth. Nelissen H, et al. Proc Natl Acad Sci U S A, 2005 May 24. PMID 15894610, Free PMC Article
    3. Elongator mediates ABA responses, oxidative stress resistance and anthocyanin biosynthesis in Arabidopsis. Zhou X, et al. Plant J, 2009 Oct. PMID 19500300
    4. Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana. Chen P, et al. BMC Plant Biol, 2010 Sep 14. PMID 20836892, Free PMC Article
    5. Plant Elongator regulates auxin-related genes during RNA polymerase II transcription elongation. Nelissen H, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080602, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. show that the Elongator (elo1, elo2, and elo3) complex was purified from plant cell cultures as a six-component complex.
      Title: Plant Elongator regulates auxin-related genes during RNA polymerase II transcription elongation.
    2. Elongator is important for plants to respond to ABA and drought exposure and that ABO1/ELO2 may play a vital role in ABA signal transduction pathways.[ABO1]
      Title: Mutations in ABO1/ELO2, a subunit of holo-Elongator, increase abscisic acid sensitivity and drought tolerance in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_121371.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within 5-carbamoylmethyl uridine residue modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to abscisic acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fruit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of anthocyanin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of auxin mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    IKI3 family protein
    NP_196872.1
    • ABA-OVERLY SENSITIVE 1 (ABO1); CONTAINS InterPro DOMAIN/s: WD40 repeat-like-containing domain (InterPro:IPR011046), IKI3 (InterPro:IPR006849); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4410314..4415622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121371.3 → NP_196872.1  IKI3 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196872.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FNA4
      UniProtKB/TrEMBL
      A0A5S9Y482
      Conserved Domains (3) summary
      COG5290
      Location:159 → 1264
      COG5290; IkappaB kinase complex, IKAP component [Transcription]
      pfam04762
      Location:1 → 953
      IKI3; IKI3 family
      sd00039
      Location:79 → 114
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FNA4.1

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