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    GAS41 YEATS family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834599, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GAS41
    Official Full Name
    YEATS family protein
    Primary source
    TAIR:AT5G45600
    Locus tag
    AT5G45600
    See related
    Araport:AT5G45600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GLIOMAS 41; homolog of yeast YAF9 a; K2N11.8; K2N11_8; TAF14B; TBP-ASSOCIATED FACTOR 14B; YAF9a
    Summary
    The GSA41 human homolog is expressed in nuclei and binds NuMA, a component of the nuclear matrix in interphase nuclei. It negatively regulates flowering by controlling the H4 acetylation levels in the FLC and FT chromatin.
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    Genomic context

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    See GAS41 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (18487798..18489869)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L35 Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis ortholog of the YEATS domain containing protein YAF9a regulates flowering by controlling H4 acetylation levels at the FLC locus. Zacharaki V, et al. Plant Sci, 2012 Nov. PMID 23017898
    2. Arabidopsis YAF9 histone readers modulate flowering time through NuA4-complex-dependent H4 and H2A.Z histone acetylation at FLC chromatin. Crevillén P, et al. New Phytol, 2019 Jun. PMID 30742710
    3. GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. Harborth J, et al. J Biol Chem, 2000 Oct 13. PMID 10913114
    4. The FRIGIDA complex activates transcription of FLC, a strong flowering repressor in Arabidopsis, by recruiting chromatin modification factors. Choi K, et al. Plant Cell, 2011 Jan. PMID 21282526, Free PMC Article
    5. The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis. Zhou JX, et al. J Integr Plant Biol, 2022 Apr. PMID 35043580

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YAF9A binds FLC chromatin and that YAF9 proteins regulate FLC expression by modulating the acetylation levels of H2A.Z and H4 but not H2A.Z deposition.
      Title: Arabidopsis YAF9 histone readers modulate flowering time through NuA4-complex-dependent H4 and H2A.Z histone acetylation at FLC chromatin.
    2. Data indicate that two ortholog of the YEATS domain containing protein At5g45600 and At2g18000 were identified, which were designated as YAF9a and YAF9b/TAF14.
      Title: The Arabidopsis ortholog of the YEATS domain containing protein YAF9a regulates flowering by controlling H4 acetylation levels at the FLC locus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203546.1
    NM_123928.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H4 acetyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of photoperiodism, flowering IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of timing of transition from vegetative to reproductive phase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    YEATS family protein
    NP_001190475.1
    • GLIOMAS 41 (GAS41); INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: YEATS (InterPro:IPR005033); BEST Arabidopsis thaliana protein match is: TBP-associated factor 14 (TAIR:AT2G18000.2).
    NP_199373.1
    • GLIOMAS 41 (GAS41); INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: YEATS (InterPro:IPR005033); BEST Arabidopsis thaliana protein match is: TBP-associated factor 14 (TAIR:AT2G18000.2); Has 807 Blast hits to 807 proteins in 219 species: Archae - 0; Bacteria - 0; Metazoa - 350; Fungi - 284; Plants - 64; Viruses - 0; Other Eukaryotes - 109 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18487798..18489869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123928.4 → NP_199373.1  YEATS family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199373.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KEK5, Q9FH40
      UniProtKB/TrEMBL
      A0A5S9YBM9, A0A654G8G2
      Conserved Domains (1) summary
      cd16910
      Location:44 → 175
      YEATS_TFIID14_like; YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins

    2. NM_001203546.1 → NP_001190475.1  YEATS family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190475.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G8G2
      Conserved Domains (1) summary
      pfam03366
      Location:66 → 145
      YEATS; YEATS family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FH40.1

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