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    ICK6 inhibitor/interactor with cyclin-dependent kinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834940, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ICK6
    Official Full Name
    inhibitor/interactor with cyclin-dependent kinase
    Primary source
    TAIR:AT5G48820
    Locus tag
    AT5G48820
    See related
    Araport:AT5G48820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    inhibitor/interactor with cyclin-dependent kinase; K24G6.15; K24G6_15; KIP-RELATED PROTEIN 3; KRP3
    Summary
    Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI), negative regulator of cell division. Binds to D type and CDC2A cyclins and may inhibit cell cycle. Seven KRP genes were found in Arabidopsis thaliana. Differential expression patterns for distinct KRPs were revealed by in situ hybridization.
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    Genomic context

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    See ICK6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (19792270..19794480, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Phototropic-responsive NPH3 family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cytochrome B5 isoform D Neighboring gene phosphoglycolate phosphatase Neighboring gene tRNA-Met

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants. Coelho RR, et al. Plant Cell Environ, 2017 Jul. PMID 28103637
    2. Downregulation of multiple CDK inhibitor ICK/KRP genes upregulates the E2F pathway and increases cell proliferation, and organ and seed sizes in Arabidopsis. Cheng Y, et al. Plant J, 2013 Aug. PMID 23647236
    3. RKP, a RING finger E3 ligase induced by BSCTV C4 protein, affects geminivirus infection by regulation of the plant cell cycle. Lai J, et al. Plant J, 2009 Mar. PMID 19000158
    4. Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-associated kinases, including plant-specific B-type cyclin-dependent kinase. Nakai T, et al. FEBS Lett, 2006 Jan 9. PMID 16376885
    5. Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis. De Veylder L, et al. Plant Cell, 2001 Jul. PMID 11449057, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KRP3 role in gall maturation and root-knot nematode feeding
      Title: Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203566.1
    NM_124259.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor/interactor with cyclin-dependent kinase
    NP_001190495.1
    • inhibitor/interactor with cyclin-dependent kinase (ICK6); CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor (InterPro:IPR003175), Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701); BEST Arabidopsis thaliana protein match is: Cyclin-dependent kinase inhibitor family protein (TAIR:AT3G24810.1).
    NP_199693.1
    • inhibitor/interactor with cyclin-dependent kinase (ICK6); CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor (InterPro:IPR003175), Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701); BEST Arabidopsis thaliana protein match is: Cyclin-dependent kinase inhibitor family protein (TAIR:AT3G24810.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19792270..19794480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203566.1 → NP_001190495.1  inhibitor/interactor with cyclin-dependent kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190495.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FEN0, F4K388
      Conserved Domains (1) summary
      pfam02234
      Location:194 → 234
      CDI; Cyclin-dependent kinase inhibitor

    2. NM_124259.2 → NP_199693.1  inhibitor/interactor with cyclin-dependent kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199693.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FKB5
      UniProtKB/TrEMBL
      A0A178UGC0, A0A5S9YC75, A0A7G2FEN0
      Conserved Domains (1) summary
      pfam02234
      Location:177 → 218
      CDI; Cyclin-dependent kinase inhibitor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FKB5.1

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