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    SWEET13 Nodulin MtN3 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835152, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SWEET13
    Official Full Name
    Nodulin MtN3 family protein
    Primary source
    TAIR:AT5G50800
    Locus tag
    AT5G50800
    See related
    Araport:AT5G50800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtSWEET13; K7B16.1; K7B16_1
    Summary
    Encodes a member of the SWEET sucrose efflux transporter family proteins.
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    Genomic context

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    See SWEET13 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (20665068..20667312, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein Neighboring gene Nodulin MtN3 family protein Neighboring gene tRNA-Gln Neighboring gene translocase inner membrane subunit 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis AtSWEET13 transporter discriminates sugars by selective facial and positional substrate recognition. Weigle AT, et al. Commun Biol, 2024 Jun 24. PMID 38914639, Free PMC Article
    2. SWEET13 transport of sucrose, but not gibberellin, restores male fertility in Arabidopsis sweet13;14. Isoda R, et al. Proc Natl Acad Sci U S A, 2022 Oct 18. PMID 36215460, Free PMC Article
    3. Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter. Han L, et al. Proc Natl Acad Sci U S A, 2017 Sep 19. PMID 28878024, Free PMC Article
    4. AtSWEET13 and AtSWEET14 regulate gibberellin-mediated physiological processes. Kanno Y, et al. Nat Commun, 2016 Oct 26. PMID 27782132, Free PMC Article
    5. Arabidopsis RPG1 is important for primexine deposition and functions redundantly with RPG2 for plant fertility at the late reproductive stage. Sun MX, et al. Plant Reprod, 2013 Jun. PMID 23686221

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis AtSWEET13 transporter discriminates sugars by selective facial and positional substrate recognition.
      Title: The Arabidopsis AtSWEET13 transporter discriminates sugars by selective facial and positional substrate recognition.
    2. SWEET13 transport of sucrose, but not gibberellin, restores male fertility in Arabidopsis sweet13;14.
      Title: SWEET13 transport of sucrose, but not gibberellin, restores male fertility in Arabidopsis sweet13;14.
    3. Results suggest that SWEET proteins AtSWEET13 and AtSWEET14 may be involved in modulating gibberellin (GA) response.
      Title: AtSWEET13 and AtSWEET14 regulate gibberellin-mediated physiological processes.
    4. report the 2.8-A resolution crystal structure of AtSWEET13 in the inward-facing conformation with a substrate analog, 2'-deoxycytidine 5'-monophosphate, bound in the central cavity.
      Title: Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter.
    5. RPG1 and RPG2 are involved in primexine deposition and therefore pollen wall pattern formation.
      Title: Arabidopsis RPG1 is important for primexine deposition and functions redundantly with RPG2 for plant fertility at the late reproductive stage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124458.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables gibberellin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sucrose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sugar transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anther dehiscence IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within callose deposition in cell wall IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within carboxylic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gibberellic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gibberellic acid transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within seed growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sucrose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nodulin MtN3 family protein
    NP_199893.1
    • Nodulin MtN3 family protein; LOCATED IN: endomembrane system, integral to membrane, membrane; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: MtN3/saliva-related transmembrane protein, conserved region (InterPro:IPR018169), RAG1-activating protein 1 homologue (InterPro:IPR018179), RAG1-activating protein-1-related (InterPro:IPR004316); BEST Arabidopsis thaliana protein match is: Nodulin MtN3 family protein (TAIR:AT4G25010.1); Has 996 Blast hits to 949 proteins in 115 species: Archae - 0; Bacteria - 0; Metazoa - 242; Fungi - 0; Plants - 618; Viruses - 0; Other Eukaryotes - 136 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20665068..20667312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124458.2 → NP_199893.1  Nodulin MtN3 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199893.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LAZ2, Q9FGQ2
      UniProtKB/TrEMBL
      A0A178UJY5, A0A5S9YCS9, A0A7G2FLP5
      Conserved Domains (1) summary
      pfam03083
      Location:132 → 218
      MtN3_slv; Sugar efflux transporter for intercellular exchange
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FGQ2.1

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